| Title |
Collaborating to improve the use of free-energy and other quantitative methods in drug discovery
|
|---|---|
| Published in |
Perspectives in Drug Discovery and Design, December 2016
|
| DOI | 10.1007/s10822-016-9996-y |
| Pubmed ID | |
| Authors |
Bradley Sherborne, Veerabahu Shanmugasundaram, Alan C. Cheng, Clara D. Christ, Renee L. DesJarlais, Jose S. Duca, Richard A. Lewis, Deborah A. Loughney, Eric S. Manas, Georgia B. McGaughey, Catherine E. Peishoff, Herman van Vlijmen |
| Abstract |
In May and August, 2016, several pharmaceutical companies convened to discuss and compare experiences with Free Energy Perturbation (FEP). This unusual synchronization of interest was prompted by Schrödinger's FEP+ implementation and offered the opportunity to share fresh studies with FEP and enable broader discussions on the topic. This article summarizes key conclusions of the meetings, including a path forward of actions for this group to aid the accelerated evaluation, application and development of free energy and related quantitative, structure-based design methods. |
X Demographics
The data shown below were collected from the profiles of 25 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 9 | 36% |
| France | 3 | 12% |
| Mexico | 2 | 8% |
| United Kingdom | 2 | 8% |
| Switzerland | 1 | 4% |
| Chile | 1 | 4% |
| Sweden | 1 | 4% |
| Spain | 1 | 4% |
| Unknown | 5 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 13 | 52% |
| Members of the public | 11 | 44% |
| Practitioners (doctors, other healthcare professionals) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 5% |
| Unknown | 42 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 32% |
| Student > Ph. D. Student | 8 | 18% |
| Student > Bachelor | 4 | 9% |
| Professor | 2 | 5% |
| Student > Master | 2 | 5% |
| Other | 5 | 11% |
| Unknown | 9 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 18 | 41% |
| Biochemistry, Genetics and Molecular Biology | 3 | 7% |
| Engineering | 3 | 7% |
| Physics and Astronomy | 2 | 5% |
| Mathematics | 1 | 2% |
| Other | 7 | 16% |
| Unknown | 10 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 March 2019.
All research outputs
#2,491,722
of 25,457,858 outputs
Outputs from Perspectives in Drug Discovery and Design
#60
of 949 outputs
Outputs of similar age
#48,087
of 422,709 outputs
Outputs of similar age from Perspectives in Drug Discovery and Design
#2
of 9 outputs
Altmetric has tracked 25,457,858 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 949 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 422,709 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 7 of them.