| Title |
Effects of psilocybin on hippocampal neurogenesis and extinction of trace fear conditioning
|
|---|---|
| Published in |
Experimental Brain Research, June 2013
|
| DOI | 10.1007/s00221-013-3579-0 |
| Pubmed ID | |
| Authors |
Briony J. Catlow, Shijie Song, Daniel A. Paredes, Cheryl L. Kirstein, Juan Sanchez-Ramos |
| Abstract |
Drugs that modulate serotonin (5-HT) synaptic concentrations impact neurogenesis and hippocampal (HPC)-dependent learning. The primary objective is to determine the extent to which psilocybin (PSOP) modulates neurogenesis and thereby affects acquisition and extinction of HPC-dependent trace fear conditioning. PSOP, the 5-HT2A agonist 25I-NBMeO and the 5-HT2A/C antagonist ketanserin were administered via an acute intraperitoneal injection to mice. Trace fear conditioning was measured as the amount of time spent immobile in the presence of the conditioned stimulus (CS, auditory tone), trace (silent interval) and post-trace interval over 10 trials. Extinction was determined by the number of trials required to resume mobility during CS, trace and post-trace when the shock was not delivered. Neurogenesis was determined by unbiased counts of cells in the dentate gyrus of the HPC birth-dated with BrdU co-expressing a neuronal marker. Mice treated with a range of doses of PSOP acquired a robust conditioned fear response. Mice injected with low doses of PSOP extinguished cued fear conditioning significantly more rapidly than high-dose PSOP or saline-treated mice. Injection of PSOP, 25I-NBMeO or ketanserin resulted in significant dose-dependent decreases in number of newborn neurons in hippocampus. At the low doses of PSOP that enhanced extinction, neurogenesis was not decreased, but rather tended toward an increase. Extinction of "fear conditioning" may be mediated by actions of the drugs at sites other than hippocampus such as the amygdala, which is known to mediate the perception of fear. Another caveat is that PSOP is not purely selective for 5-HT2A receptors. PSOP facilitates extinction of the classically conditioned fear response, and this, and similar agents, should be explored as potential treatments for post-traumatic stress disorder and related conditions. |
X Demographics
The data shown below were collected from the profiles of 176 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 42 | 24% |
| Canada | 7 | 4% |
| United Kingdom | 6 | 3% |
| South Africa | 4 | 2% |
| France | 3 | 2% |
| Spain | 2 | 1% |
| Norway | 2 | 1% |
| Portugal | 1 | <1% |
| Germany | 1 | <1% |
| Other | 10 | 6% |
| Unknown | 98 | 56% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 152 | 86% |
| Practitioners (doctors, other healthcare professionals) | 12 | 7% |
| Scientists | 10 | 6% |
| Science communicators (journalists, bloggers, editors) | 2 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 511 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | <1% |
| United Kingdom | 2 | <1% |
| Brazil | 2 | <1% |
| Switzerland | 1 | <1% |
| Netherlands | 1 | <1% |
| Portugal | 1 | <1% |
| Russia | 1 | <1% |
| Italy | 1 | <1% |
| Unknown | 499 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 121 | 24% |
| Student > Ph. D. Student | 65 | 13% |
| Researcher | 58 | 11% |
| Student > Master | 54 | 11% |
| Other | 26 | 5% |
| Other | 67 | 13% |
| Unknown | 120 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 98 | 19% |
| Psychology | 59 | 12% |
| Agricultural and Biological Sciences | 58 | 11% |
| Medicine and Dentistry | 49 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 31 | 6% |
| Other | 81 | 16% |
| Unknown | 135 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 319. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 April 2024.
All research outputs
#108,151
of 25,770,491 outputs
Outputs from Experimental Brain Research
#7
of 3,414 outputs
Outputs of similar age
#646
of 206,620 outputs
Outputs of similar age from Experimental Brain Research
#1
of 53 outputs
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So far Altmetric has tracked 3,414 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one has done particularly well, scoring higher than 99% of its peers.
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