| Title |
Developmental Markers of Genetic Liability to Autism in Parents: A Longitudinal, Multigenerational Study
|
|---|---|
| Published in |
Journal of Autism and Developmental Disorders, January 2017
|
| DOI | 10.1007/s10803-016-2996-x |
| Pubmed ID | |
| Authors |
Molly Losh, Gary E. Martin, Michelle Lee, Jessica Klusek, John Sideris, Sheila Barron, Thomas Wassink |
| Abstract |
Genetic liability to autism spectrum disorder (ASD) can be expressed in unaffected relatives through subclinical, genetically meaningful traits, or endophenotypes. This study aimed to identify developmental endophenotypes in parents of individuals with ASD by examining parents' childhood academic development over the school-age period. A cohort of 139 parents of individuals with ASD were studied, along with their children with ASD and 28 controls. Parents' childhood records in the domains of language, reading, and math were studied from grades K-12. Results indicated that relatively lower performance and slower development of skills (particularly language related skills), and an uneven rate of development across domains predicted ASD endophenotypes in adulthood for parents, and the severity of clinical symptoms in children with ASD. These findings may mark childhood indicators of genetic liability to ASD in parents, that could inform understanding of the subclinical expression of ASD genetic liability. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 14% |
| Canada | 1 | 14% |
| Japan | 1 | 14% |
| Unknown | 4 | 57% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 86% |
| Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 108 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Unknown | 107 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 17 | 16% |
| Student > Ph. D. Student | 16 | 15% |
| Researcher | 13 | 12% |
| Student > Bachelor | 11 | 10% |
| Student > Doctoral Student | 10 | 9% |
| Other | 12 | 11% |
| Unknown | 29 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 35 | 32% |
| Social Sciences | 8 | 7% |
| Linguistics | 3 | 3% |
| Biochemistry, Genetics and Molecular Biology | 3 | 3% |
| Neuroscience | 3 | 3% |
| Other | 17 | 16% |
| Unknown | 39 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 January 2017.
All research outputs
#7,496,932
of 25,758,695 outputs
Outputs from Journal of Autism and Developmental Disorders
#2,619
of 5,442 outputs
Outputs of similar age
#127,764
of 425,110 outputs
Outputs of similar age from Journal of Autism and Developmental Disorders
#38
of 76 outputs
Altmetric has tracked 25,758,695 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 5,442 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.5. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 425,110 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 76 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.