| Title |
Increased pain from muscle fascia following eccentric exercise: animal and human findings
|
|---|---|
| Published in |
Experimental Brain Research, January 2009
|
| DOI | 10.1007/s00221-008-1699-8 |
| Pubmed ID | |
| Authors |
William Gibson, Lars Arendt-Nielsen, Toru Taguchi, Kazue Mizumura, Thomas Graven-Nielsen |
| Abstract |
Mechanisms and structures which are involved in eccentric exercise-induced delayed onset muscle soreness (DOMS) are not yet clarified. Tissue and site specificity may be important considerations in afferent sensitisation following eccentric exercise. This study investigated the nociceptive response to hypertonic sodium solution applied to fascial/epimysium tissue and mechanically sensitised sites in muscle by assessing (1) afferent recordings in animals and (2) psychophysical assessment in humans. Seventeen male rats underwent eccentric contraction of extensor digitorum longus muscle, while 11 rats served as an unexercised naïve group. Two days post-exercise, group IV afferent fibre activity was recorded in response to superfusion of hypertonic Krebs solution on the mechanically sensitised muscle/epimysium site. Mechanical sensitisation was confirmed with significant increases in afferent response and decreases in threshold to mechanical stimulation in the eccentrically exercised rats compared to naïve rats. There was no difference in afferent response magnitude to hypertonic Krebs solution between exercise and naïve groups. In the human study, 13 volunteers participated. After bilateral assessment of pressure pain thresholds (PPT) along the tibialis anterior muscles, eccentric exercise was performed to induce DOMS in m. tibialis anterior of one leg. Site of maximal mechanical sensitivity was identified 24 h later and injected with hypertonic saline at fascial and deep muscle levels. The corresponding site on the opposite unexercised leg served as a control. Fascial injection of the exercised muscle caused significantly higher pain intensity compared to all other injections. Response to deep muscle stimulation was not different between sides. This suggests that fascia rather than muscle tissue is important in DOMS associated sensitisation. |
X Demographics
The data shown below were collected from the profiles of 19 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 3 | 16% |
| United States | 3 | 16% |
| United Kingdom | 3 | 16% |
| Ireland | 1 | 5% |
| Finland | 1 | 5% |
| Canada | 1 | 5% |
| Unknown | 7 | 37% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 63% |
| Scientists | 5 | 26% |
| Practitioners (doctors, other healthcare professionals) | 2 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 142 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Unknown | 140 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 12% |
| Student > Master | 15 | 11% |
| Student > Bachelor | 15 | 11% |
| Researcher | 13 | 9% |
| Student > Postgraduate | 13 | 9% |
| Other | 47 | 33% |
| Unknown | 22 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 44 | 31% |
| Sports and Recreations | 24 | 17% |
| Nursing and Health Professions | 13 | 9% |
| Agricultural and Biological Sciences | 7 | 5% |
| Neuroscience | 6 | 4% |
| Other | 19 | 13% |
| Unknown | 29 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 27. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 November 2016.
All research outputs
#1,220,769
of 22,711,645 outputs
Outputs from Experimental Brain Research
#76
of 3,218 outputs
Outputs of similar age
#4,956
of 170,109 outputs
Outputs of similar age from Experimental Brain Research
#1
of 13 outputs
Altmetric has tracked 22,711,645 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,218 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one has done particularly well, scoring higher than 97% of its peers.
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We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.