| Title |
Clinical observation of Shuanghuang Shengbai Granule (双黄升白颗粒) on prevention and treatment of myelosuppression caused by chemotherapy in cancer patients
|
|---|---|
| Published in |
Chinese Journal of Integrative Medicine, August 2016
|
| DOI | 10.1007/s11655-016-2503-4 |
| Pubmed ID | |
| Authors |
Li-fang Wang, Zhen-ye Xu, Zhong-qi Wang, Ming Zhang, Gui-ying Yan, An-ji Hou, Hai-bin Deng, Ji Wu, Xiao-zhen Zhao, Yi Xiang, Lei Yu |
| Abstract |
To study the efficacy and safety of Shuanghuang Shengbai Granule (, SSG), a traditional Chinese herbal medicine, on myelosuppression of cancer patients caused by chemotherapy. A total of 330 patients were randomly assigned to the treatment group (220 cases, analysed 209 cases) and the control group (110 cases, analysed 102 cases) with a 2:1 ratio by envelope method. The patients in the treatment group at the first day of chemotherapy started to take SSG for 14 days, while the patients in the control group took Leucogon Tablets. The changes of the blood routine, clinical symptoms and immune function in both groups were observed for safety and efficacy evaluation. At the 7th day of chemotherapy, the white blood cells (WBCs) level in the treatment group was significantly higher than that in the control group (P<0.05). After treatment, the WBCs rate in the normal range accounted for 50.2% in the treatment group, the myelosuppression of WBCs and neutrophil were mainly grade I, while 8.1% and 5.7% of patients emerged grade III and grade IV myelosuppression, respectively. The incidence of myelosuppression of the treatment group was significantly lower than that of the control group (P<0.05). The total effective rate of Chinese medicine syndrome in the treatment group was significantly higher than that in the control group (84.2% vs. 72.5%, P<0.05). The immune cell levels in both groups were maintained in the normal range. Compared with that before treatment, the levels of CD3(+) and CD4(+) cells were significantly increased in the treatment group after treatment (P<0.05). The discrepancy of CD3(+) and CD4(+) cell activity before and after treatment in both groups were significantly different (P<0.05). No obvious adverse event occurred in both groups. SSG had a protection effect on bone marrow suppression, and alleviated the clinical symptoms together with clinical safety. |
Mendeley readers
The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 29 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 5 | 17% |
| Researcher | 4 | 14% |
| Other | 3 | 10% |
| Student > Master | 2 | 7% |
| Student > Doctoral Student | 1 | 3% |
| Other | 3 | 10% |
| Unknown | 11 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 38% |
| Psychology | 2 | 7% |
| Agricultural and Biological Sciences | 1 | 3% |
| Unspecified | 1 | 3% |
| Sports and Recreations | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 12 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 February 2019.
All research outputs
#7,582,018
of 23,767,404 outputs
Outputs from Chinese Journal of Integrative Medicine
#154
of 689 outputs
Outputs of similar age
#127,060
of 370,749 outputs
Outputs of similar age from Chinese Journal of Integrative Medicine
#7
of 24 outputs
Altmetric has tracked 23,767,404 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 689 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done well, scoring higher than 76% of its peers.
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We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.