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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The autoimmune risk gene ZMIZ1 is a vitamin D responsive marker of a molecular phenotype of multiple sclerosis
|
|---|---|
| Published in |
Journal of Autoimmunity, January 2017
|
| DOI | 10.1016/j.jaut.2016.12.006 |
| Pubmed ID | |
| Authors |
N.L. Fewings, P.N. Gatt, F.C. McKay, G.P. Parnell, S.D. Schibeci, J. Edwards, M.A. Basuki, A. Goldinger, M.J. Fabis-Pedrini, A.G. Kermode, C.P. Manrique, J.L. McCauley, D. Nickles, S.E. Baranzini, T. Burke, S. Vucic, G.J. Stewart, D.R. Booth |
| Abstract |
Multiple Sclerosis (MS) is a neurological condition driven in part by immune cells from the peripheral circulation, the targets for current successful therapies. The autoimmune and MS risk gene ZMIZ1 is underexpressed in blood in people with MS. We show that, from three independent sets of transcriptomic data, expression of ZMIZ1 is tightly correlated with that of hundreds of other genes. Further we show expression is partially heritable (heritability 0.26), relatively stable over time, predominantly in plasmacytoid dendritic cells and non-classical monocytes, and that levels of ZMIZ1 protein expression are reduced in MS. ZMIZ1 gene expression is increased in response to calcipotriol (1,25 Vitamin D3) (p < 0.0003) and associated with Epstein Barr Virus (EBV) EBNA-1 antibody titre (p < 0.004). MS therapies fingolimod and dimethyl fumarate altered blood ZMIZ1 gene expression compared to untreated MS. The phenotype indicates susceptibility to MS, and may correspond with clinical response and represent a novel clinical target. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 75 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 11 | 15% |
| Student > Bachelor | 9 | 12% |
| Student > Ph. D. Student | 8 | 11% |
| Student > Doctoral Student | 7 | 9% |
| Researcher | 6 | 8% |
| Other | 10 | 13% |
| Unknown | 24 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 15 | 20% |
| Biochemistry, Genetics and Molecular Biology | 11 | 15% |
| Immunology and Microbiology | 6 | 8% |
| Agricultural and Biological Sciences | 5 | 7% |
| Neuroscience | 5 | 7% |
| Other | 6 | 8% |
| Unknown | 27 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 December 2017.
All research outputs
#17,285,668
of 25,374,647 outputs
Outputs from Journal of Autoimmunity
#1,310
of 1,650 outputs
Outputs of similar age
#267,878
of 421,996 outputs
Outputs of similar age from Journal of Autoimmunity
#15
of 20 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,650 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.5. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 421,996 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.