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Mendeley readers
Attention Score in Context
| Title |
Efficient Biodistribution and Gene Silencing in the Lung epithelium via Intravenous Liposomal Delivery of siRNA
|
|---|---|
| Published in |
Molecular Therapy - Nucleic Acids, June 2013
|
| DOI | 10.1038/mtna.2013.22 |
| Pubmed ID | |
| Authors |
Jana McCaskill, Richa Singhania, Melinda Burgess, Rachel Allavena, Sherry Wu, Antje Blumenthal, Nigel AJ McMillan |
| Abstract |
RNA interference (RNAi) may provide a therapeutic solution to many pulmonary epithelium diseases. However, the main barrier to the clinical use of RNAi remains the lack of efficient delivery vectors. Research has mainly concentrated on the intranasal route of delivery of short interfering RNA (siRNA) effector molecules for the treatment of respiratory diseases. However, this may be complicated in a diseased state due to the increased fluid production and tissue remodeling. Therefore, we investigated our hydration of a freeze-dried matrix (HFDM) formulated liposomes for systemic delivery to the lung epithelium. Here, we show that 45 ± 2% of epithelial murine lung cells receive siRNA delivery upon intravenous (IV) liposomal administration. Furthermore, we demonstrate that liposomal siRNA delivery resulted in targeted gene and protein knockdown throughout the lung, including lung epithelium. Taken together, this is the first description of lung epithelial delivery via cationic liposomes, and provides a proof of concept for the use of IV liposomal RNAi delivery to specifically knockdown targeted genes in the respiratory system. This approach may provide an attractive alternate therapeutic delivery strategy for the treatment of lung epithelium diseases.Molecular Therapy - Nucleic Acids (2013) 2, e96; doi:10.1038/mtna.2013.22; published online 4 June 2013. |
Mendeley readers
The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| Netherlands | 1 | 1% |
| Turkey | 1 | 1% |
| India | 1 | 1% |
| Australia | 1 | 1% |
| Unknown | 73 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 28% |
| Student > Master | 12 | 15% |
| Researcher | 11 | 14% |
| Student > Doctoral Student | 9 | 11% |
| Other | 6 | 8% |
| Other | 10 | 13% |
| Unknown | 9 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 13 | 16% |
| Biochemistry, Genetics and Molecular Biology | 12 | 15% |
| Medicine and Dentistry | 11 | 14% |
| Chemistry | 6 | 8% |
| Engineering | 6 | 8% |
| Other | 18 | 23% |
| Unknown | 13 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 June 2013.
All research outputs
#22,758,309
of 25,371,288 outputs
Outputs from Molecular Therapy - Nucleic Acids
#1,591
of 1,841 outputs
Outputs of similar age
#184,981
of 209,898 outputs
Outputs of similar age from Molecular Therapy - Nucleic Acids
#17
of 17 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,841 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 209,898 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.