| Title |
Exosomal microRNAs in liquid biopsies: future biomarkers for prostate cancer
|
|---|---|
| Published in |
Clinical and Translational Oncology, January 2017
|
| DOI | 10.1007/s12094-016-1599-5 |
| Pubmed ID | |
| Authors |
A. Valentino, P. Reclusa, R. Sirera, M. Giallombardo, C. Camps, P. Pauwels, S. Crispi, C. Rolfo |
| Abstract |
Prostate cancer is the second most diagnosed cancer in males in the world. Plasma quantification of prostate-specific antigen substantially improved the early detection of prostate cancer, but still lacks the required specificity. Clinical management of prostate cancer needs advances in the development of new non-invasive biomarkers, ameliorating current diagnosis and prognosis and guiding therapeutic decisions. microRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression at the post-transcriptional level. These miRNAs are expressed in the cells and are also present in cell-derived extracellular vesicles such as exosomes. Exosomes have been shown to act as mediators for cell to cell communication because of the regulatory functions of their content. High levels of exosomes are found in several body fluids from cancer patients and could be a potential source of non-invasive biomarkers. In this review, we summarize the diagnostic and prognostic utility of exosomal miRNAs in prostate cancer. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Colombia | 1 | 20% |
| Japan | 1 | 20% |
| Canada | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 138 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 138 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 26 | 19% |
| Researcher | 21 | 15% |
| Student > Master | 19 | 14% |
| Student > Bachelor | 15 | 11% |
| Other | 10 | 7% |
| Other | 22 | 16% |
| Unknown | 25 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 43 | 31% |
| Medicine and Dentistry | 21 | 15% |
| Agricultural and Biological Sciences | 18 | 13% |
| Immunology and Microbiology | 4 | 3% |
| Engineering | 4 | 3% |
| Other | 16 | 12% |
| Unknown | 32 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 March 2018.
All research outputs
#13,283,951
of 22,931,367 outputs
Outputs from Clinical and Translational Oncology
#531
of 1,312 outputs
Outputs of similar age
#206,539
of 421,235 outputs
Outputs of similar age from Clinical and Translational Oncology
#11
of 27 outputs
Altmetric has tracked 22,931,367 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,312 research outputs from this source. They receive a mean Attention Score of 3.7. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 421,235 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.