Title |
Vitamin D and diabetes mellitus: Causal or casual association?
|
---|---|
Published in |
Reviews in Endocrine and Metabolic Disorders, January 2017
|
DOI | 10.1007/s11154-016-9403-y |
Pubmed ID | |
Authors |
M. Grammatiki, E. Rapti, S. Karras, R. A. Ajjan, Kalliopi Kotsa |
Abstract |
The incidence of both type 2 and type 1 diabetes mellitus has been increasing worldwide. Vitamin D deficiency, or the awareness of its prevalence, has also been increasing. Vitamin D may have a role in the pathogenic mechanisms predisposing to type 2 diabetes by modulating insulin resistance and/or pancreatic β-cell function. Vitamin D status or elements involved in its activation or transport may also be involved in the development of type 1 diabetes mellitus through immunomodulatory role . Based on these observations a potential association between vitamin D and diabetes has been hypothesized. In this review we discuss up to date evidence linking vitamin D with the development of diabetes. Moreover, the role of vitamin D supplementation in the prevention of both types of diabetes is analysed together with its role in improving glycemic control in diabetic patients. We also address the potential role of vitamin D deficiency in the development of macro- and microvascular complications in diabetes. Finally, we provide recommendation for Vitamin D therapy in diabetes in view of current evidence and highlight areas for potential future research in this area. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 25% |
United Kingdom | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
Unknown | 172 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 28 | 16% |
Student > Bachelor | 22 | 13% |
Student > Postgraduate | 14 | 8% |
Researcher | 12 | 7% |
Other | 11 | 6% |
Other | 32 | 18% |
Unknown | 54 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 64 | 37% |
Nursing and Health Professions | 16 | 9% |
Biochemistry, Genetics and Molecular Biology | 9 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 4% |
Agricultural and Biological Sciences | 5 | 3% |
Other | 11 | 6% |
Unknown | 61 | 35% |