Title |
Alterations in Expression Pattern of Splicing Factors in Epithelial Ovarian Cancer and its Clinical Impact
|
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Published in |
International Journal of Gynecological Cancer, April 2013
|
DOI | 10.1097/igc.0b013e31829783e3 |
Pubmed ID | |
Authors |
Severine Iborra, Marc Hirschfeld, Markus Jaeger, Axel zur Hausen, Iona Braicu, Jalid Sehouli, Gerald Gitsch, Elmar Stickeler |
Abstract |
Alternative splicing represents an important nuclear mechanism in the posttranscriptional regulation of gene expression, which is frequently altered during tumorigenesis. Previously, we described marked changes in alternative splicing of the CD44 gene in ovarian and breast cancer as well as specific induction of distinct splicing factors during tumor development. The present study was focused on the expression profiles of different splicing factors, including classical serine-arginine (SR) proteins including ASF/SF2, hTra2β1, hTra2α, and Y-box-binding protein (YB-1) in physiological and malignant epithelial ovarian tissue to evaluate their expression pattern with regard to tumor development and disease progression. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 32 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 34% |
Student > Bachelor | 6 | 19% |
Student > Master | 2 | 6% |
Student > Postgraduate | 2 | 6% |
Researcher | 2 | 6% |
Other | 1 | 3% |
Unknown | 8 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 13 | 41% |
Agricultural and Biological Sciences | 7 | 22% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Veterinary Science and Veterinary Medicine | 1 | 3% |
Medicine and Dentistry | 1 | 3% |
Other | 1 | 3% |
Unknown | 8 | 25% |