| Title |
Activation of PARP by Oxidative Stress Induced by β-Amyloid: Implications for Alzheimer’s Disease
|
|---|---|
| Published in |
Neurochemical Research, October 2012
|
| DOI | 10.1007/s11064-012-0895-x |
| Pubmed ID | |
| Authors |
Rosella Abeti, Michael R. Duchen |
| Abstract |
Alzheimer's disease (AD) is a major neurodegenerative disease of old age, characterised by progressive cognitive impairment, dementia and atrophy of the central nervous system. The pathological hallmarks include the accumulation of the peptide β-amyloid (Aβ) which itself is toxic to neurons in culture. Recently, it has been discovered that Aβ activates the protein poly(ADP-ribosyl) polymerase-1 (PARP-1) specifically in astrocytes, leading indirectly to neuronal cell death. PARP-1 is a DNA repair enzyme, normally activated by single strand breaks associated with oxidative stress, which catalyses the formation of poly ADP-ribose polymers from nicotinamide adenine dinucleotide (NAD(+)). The pathological over activation of PARP-1 causes depletion of NAD(+) and leads to cell death. Here we review the relationship between AD and PARP-1, and explore the role played by astrocytes in neuronal death. AD has so far proven refractory to any effective treatment. Identification of these pathways represents a step towards a greater understanding of the pathophysiology of this devastating disease with the potential to explore novel therapeutic targets. |
Mendeley readers
The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 76 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 16% |
| Student > Bachelor | 12 | 16% |
| Student > Master | 12 | 16% |
| Researcher | 10 | 13% |
| Professor | 5 | 7% |
| Other | 10 | 13% |
| Unknown | 15 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 16 | 21% |
| Neuroscience | 13 | 17% |
| Biochemistry, Genetics and Molecular Biology | 12 | 16% |
| Medicine and Dentistry | 8 | 11% |
| Psychology | 3 | 4% |
| Other | 7 | 9% |
| Unknown | 17 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 June 2013.
All research outputs
#20,194,368
of 22,711,645 outputs
Outputs from Neurochemical Research
#1,686
of 2,088 outputs
Outputs of similar age
#156,238
of 175,921 outputs
Outputs of similar age from Neurochemical Research
#10
of 13 outputs
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