| Title |
Glucose inhibits the insulin-induced activation of the insulin-degrading enzyme in HepG2 cells
|
|---|---|
| Published in |
Diabetologia, April 2009
|
| DOI | 10.1007/s00125-009-1350-7 |
| Pubmed ID | |
| Authors |
O. Pivovarova, Ö. Gögebakan, A. F. H. Pfeiffer, N. Rudovich |
| Abstract |
Hepatic insulin degradation decreases in type 2 diabetes. Insulin-degrading enzyme (IDE) plays a key role in insulin degradation and its gene is located in a diabetes-associated chromosomal region. We hypothesised that IDE may be regulated by insulin and/or glucose in a liver cell model. To validate the observed regulation of IDE in vivo, we analysed biopsies of human adipose tissue during different clamp experiments in men. |
Mendeley readers
The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 3% |
| Unknown | 32 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 8 | 24% |
| Student > Ph. D. Student | 4 | 12% |
| Researcher | 3 | 9% |
| Student > Postgraduate | 3 | 9% |
| Student > Master | 3 | 9% |
| Other | 6 | 18% |
| Unknown | 6 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 24% |
| Agricultural and Biological Sciences | 7 | 21% |
| Biochemistry, Genetics and Molecular Biology | 4 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
| Neuroscience | 2 | 6% |
| Other | 2 | 6% |
| Unknown | 8 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 February 2011.
All research outputs
#3,697,254
of 22,711,645 outputs
Outputs from Diabetologia
#1,691
of 5,029 outputs
Outputs of similar age
#14,396
of 92,974 outputs
Outputs of similar age from Diabetologia
#7
of 28 outputs
Altmetric has tracked 22,711,645 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,029 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.6. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 92,974 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.