| Title |
Yin and Yang of hypothalamic insulin and leptin signaling in regulating white adipose tissue metabolism
|
|---|---|
| Published in |
Reviews in Endocrine and Metabolic Disorders, June 2011
|
| DOI | 10.1007/s11154-011-9190-4 |
| Pubmed ID | |
| Authors |
Thomas Scherer, Christoph Buettner |
| Abstract |
Fatty acids released from white adipose tissue (WAT) provide important energy substrates during fasting. However, uncontrolled fatty acid release from WAT during non-fasting states causes lipotoxicity and promotes inflammation and insulin resistance, which can lead to and worsen type 2 diabetes (DM2). WAT is also a source for insulin sensitizing fatty acids such as palmitoleate produced during de novo lipogenesis. Insulin and leptin are two major hormonal adiposity signals that control energy homeostasis through signaling in the central nervous system. Both hormones have been implicated to regulate both WAT lipolysis and de novo lipogenesis through the mediobasal hypothalamus (MBH) in an opposing fashion independent of their respective peripheral receptors. Here, we review the current literature on brain leptin and insulin action in regulating WAT metabolism and discuss potential mechanisms and neuro-anatomical substrates that could explain the opposing effects of central leptin and insulin. Finally, we discuss the role of impaired hypothalamic control of WAT metabolism in the pathogenesis of insulin resistance, metabolic inflexibility and type 2 diabetes. |
Mendeley readers
The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Austria | 2 | 2% |
| Germany | 1 | 1% |
| Netherlands | 1 | 1% |
| Brazil | 1 | 1% |
| United Kingdom | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 81 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 20% |
| Student > Master | 17 | 19% |
| Researcher | 13 | 15% |
| Student > Bachelor | 9 | 10% |
| Student > Doctoral Student | 7 | 8% |
| Other | 13 | 15% |
| Unknown | 11 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 32 | 36% |
| Medicine and Dentistry | 16 | 18% |
| Biochemistry, Genetics and Molecular Biology | 15 | 17% |
| Neuroscience | 7 | 8% |
| Engineering | 2 | 2% |
| Other | 5 | 6% |
| Unknown | 11 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 April 2012.
All research outputs
#3,969,068
of 23,911,072 outputs
Outputs from Reviews in Endocrine and Metabolic Disorders
#125
of 505 outputs
Outputs of similar age
#20,280
of 118,012 outputs
Outputs of similar age from Reviews in Endocrine and Metabolic Disorders
#2
of 3 outputs
Altmetric has tracked 23,911,072 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 505 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.5. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 118,012 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.