Title |
Polyamine-trypanothione pathway: an update
|
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Published in |
Future Medicinal Chemistry, December 2016
|
DOI | 10.4155/fmc-2016-0180 |
Pubmed ID | |
Authors |
Andrea Ilari, Annarita Fiorillo, Ilaria Genovese, Gianni Colotti |
Abstract |
In trypanosomatids, polyamine and trypanothione pathways can be considered as a whole unique metabolism, where most enzymes are essential for parasitic survival and infectivity. Leishmania parasites and all the other members of the Trypanosomatids family depend on polyamines for growth and survival: the enzymes involved in the synthesis and utilization of spermidine and trypanothione, i.e., arginase, ornithine decarboxylase, S-adenosylmethionine decarboxylase, spermidine synthase and in particular trypanothione synthetase-amidase, trypanothione reductase and tryparedoxin-dependent peroxidase are promising targets for drug development. This review deals with recent structure-based studies on these enzymes, aimed at the discovery of inhibitors of this pathway. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 41 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 17% |
Student > Bachelor | 5 | 12% |
Researcher | 5 | 12% |
Professor | 3 | 7% |
Student > Master | 2 | 5% |
Other | 5 | 12% |
Unknown | 14 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 9 | 22% |
Chemistry | 7 | 17% |
Agricultural and Biological Sciences | 4 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 7% |
Immunology and Microbiology | 2 | 5% |
Other | 2 | 5% |
Unknown | 14 | 34% |