Title |
Serum lactate dehydrogenase profile as a retrospective indicator of uterine preparedness for labor: a prospective, observational study
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Published in |
BMC Pregnancy and Childbirth, June 2013
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DOI | 10.1186/1471-2393-13-128 |
Pubmed ID | |
Authors |
Jeremy L Neal, Nancy K Lowe, Elizabeth J Corwin |
Abstract |
Lactate dehydrogenase (LDH) isoenzymes are required for adenosine triphosphate production, with each of five different isoenzymes having varying proficiencies in anaerobic versus aerobic environments. With advancing pregnancy, the isoenzyme profile in uterine muscle shifts toward a more anaerobic profile, speculatively to facilitate uterine efficiency during periods of low oxygen that accompany labor contractions. Profile shifting may even occur throughout labor. Maternal serum LDH levels between 24-48 hours following delivery predominantly originate from uterine muscle, reflecting the enzymatic state of the myometrium during labor. Our purpose was to describe serum LDH isoenzymes 24-30 hours post-delivery to determine if cervical dilation rates following labor admission were associated with a particular LDH profile. We also compared differences in post-delivery LDH isoenzyme profiles between women admitted in pre-active versus established active labor. |
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