| Title |
Potential importance of B cells in aging and aging-associated neurodegenerative diseases
|
|---|---|
| Published in |
Seminars in Immunopathology, January 2017
|
| DOI | 10.1007/s00281-016-0615-8 |
| Pubmed ID | |
| Authors |
Arya Biragyn, Maria Aliseychik, Evgeny Rogaev |
| Abstract |
Our understanding of B cells as merely antibody producers is slowly changing. Alone or in concert with antibody, they control outcomes of seemingly different diseases such as cancer, rheumatoid arthritis, diabetes, and multiple sclerosis. While their role in activation of effector immune cells is beneficial in cancer but bad in autoimmune diseases, their immunosuppressive and regulatory subsets (Bregs) inhibit autoimmune and anticancer responses. These pathogenic and suppressive functions are not static and appear to be regulated by the nature and strength of inflammation. Although aging increases inflammation and changes the composition and function of B cells, surprisingly, little is known whether the change affects aging-associated neurodegenerative disease, such as Alzheimer's disease (AD). Here, by analyzing B cells in cancer and autoimmune and neuroinflammatory diseases, we elucidate their potential importance in AD and other aging-associated neuroinflammatory diseases. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 67% |
| Italy | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 64 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 13% |
| Student > Master | 8 | 13% |
| Student > Bachelor | 7 | 11% |
| Researcher | 6 | 9% |
| Student > Postgraduate | 4 | 6% |
| Other | 13 | 20% |
| Unknown | 18 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 9 | 14% |
| Medicine and Dentistry | 9 | 14% |
| Immunology and Microbiology | 7 | 11% |
| Neuroscience | 6 | 9% |
| Psychology | 3 | 5% |
| Other | 7 | 11% |
| Unknown | 23 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 January 2017.
All research outputs
#14,255,513
of 22,940,083 outputs
Outputs from Seminars in Immunopathology
#351
of 550 outputs
Outputs of similar age
#228,964
of 422,128 outputs
Outputs of similar age from Seminars in Immunopathology
#5
of 8 outputs
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So far Altmetric has tracked 550 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.5. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
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We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.