| Title |
International Osteoporosis Foundation and European Calcified Tissue Society Working Group. Recommendations for the screening of adherence to oral bisphosphonates
|
|---|---|
| Published in |
Osteoporosis International, January 2017
|
| DOI | 10.1007/s00198-017-3906-6 |
| Pubmed ID | |
| Authors |
A. Diez-Perez, K. E. Naylor, B. Abrahamsen, D. Agnusdei, M. L. Brandi, C. Cooper, E. Dennison, E. F. Eriksen, D. T. Gold, N. Guañabens, P. Hadji, M. Hiligsmann, R. Horne, R. Josse, J. A. Kanis, B. Obermayer-Pietsch, D. Prieto-Alhambra, J.-Y. Reginster, R. Rizzoli, S. Silverman, M. C. Zillikens, R. Eastell, Adherence Working Group of the International Osteoporosis Foundation and the European Calcified Tissue Society |
| Abstract |
Adherence to oral bisphosphonates is low. A screening strategy is proposed based on the response of biochemical markers of bone turnover after 3 months of therapy. If no change is observed, the clinician should reassess the adherence to the treatment and also other potential issues with the drug. Low adherence to oral bisphosphonates is a common problem that jeopardizes the efficacy of treatment of osteoporosis. No clear screening strategy for the assessment of compliance is widely accepted in these patients. The International Osteoporosis Foundation and the European Calcified Tissue Society have convened a working group to propose a screening strategy to detect a lack of adherence to these drugs. The question to answer was whether the bone turnover markers (BTMs) PINP and CTX can be used to identify low adherence in patients with postmenopausal osteoporosis initiating oral bisphosphonates for osteoporosis. The findings of the TRIO study specifically address this question and were used as the basis for testing the hypothesis. Based on the findings of the TRIO study, specifically addressing this question, the working group recommends measuring PINP and CTX at baseline and 3 months after starting therapy to check for a decrease above the least significant change (decrease of more than 38% for PINP and 56% for CTX). Detection rate for the measurement of PINP is 84%, for CTX 87% and, if variation in at least one is considered when measuring both, the level of detection is 94.5%. If a significant decrease is observed, the treatment can continue, but if no decrease occurs, the clinician should reassess to identify problems with the treatment, mainly low adherence. |
X Demographics
The data shown below were collected from the profiles of 25 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 5 | 20% |
| Spain | 3 | 12% |
| Venezuela, Bolivarian Republic of | 2 | 8% |
| France | 2 | 8% |
| Belgium | 1 | 4% |
| Argentina | 1 | 4% |
| Italy | 1 | 4% |
| Netherlands | 1 | 4% |
| Mexico | 1 | 4% |
| Other | 2 | 8% |
| Unknown | 6 | 24% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 18 | 72% |
| Scientists | 5 | 20% |
| Science communicators (journalists, bloggers, editors) | 2 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 144 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 144 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 21 | 15% |
| Researcher | 15 | 10% |
| Student > Ph. D. Student | 15 | 10% |
| Other | 13 | 9% |
| Professor | 11 | 8% |
| Other | 35 | 24% |
| Unknown | 34 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 58 | 40% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 6% |
| Nursing and Health Professions | 6 | 4% |
| Biochemistry, Genetics and Molecular Biology | 5 | 3% |
| Agricultural and Biological Sciences | 3 | 2% |
| Other | 12 | 8% |
| Unknown | 52 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 60. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 March 2017.
All research outputs
#633,035
of 23,692,259 outputs
Outputs from Osteoporosis International
#71
of 3,747 outputs
Outputs of similar age
#14,719
of 422,077 outputs
Outputs of similar age from Osteoporosis International
#4
of 81 outputs
Altmetric has tracked 23,692,259 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,747 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.7. This one has done particularly well, scoring higher than 98% of its peers.
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We're also able to compare this research output to 81 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.