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YAP/TEAD–Mediated Transcription Controls Cellular Senescence

Overview of attention for article published in Cancer Research, June 2013
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  • Good Attention Score compared to outputs of the same age (74th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

Mentioned by

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2 X users
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3 patents
peer_reviews
1 peer review site

Citations

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128 Dimensions

Readers on

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143 Mendeley
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1 CiteULike
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Title
YAP/TEAD–Mediated Transcription Controls Cellular Senescence
Published in
Cancer Research, June 2013
DOI 10.1158/0008-5472.can-12-3793
Pubmed ID
Authors

Qi Xie, Jing Chen, Han Feng, Shengyi Peng, Ursula Adams, Yujie Bai, Li Huang, Ji Li, Junjian Huang, Songshu Meng, Zengqiang Yuan

Abstract

Transcription coactivator Yes-associated protein (YAP) plays an important role in the regulation of cell proliferation and apoptosis. Here, we identify a new role of YAP in the regulation of cellular senescence. We find that the expression levels of YAP proteins decrease following the replication-induced cellular senescence in IMR90 cells. Silencing of YAP inhibits cell proliferation and induces premature senescence. In additional experiments, we observe that cellular senescence induced by YAP deficiency is TEAD- and Rb/p16/p53-dependent. Furthermore, we show that Cdk6 is a direct downstream target gene of YAP in the regulation of cellular senescence, and the expression of Cdk6 is through the YAP-TEAD complex. Ectopic expression of Cdk6 rescued YAP knockdown-induced senescence. Finally, we find that downregulation of YAP in tumor cells increases senescence in response to chemotherapeutic agents, and YAP or Cdk6 expression rescues cellular senescence. Taken together, our findings define the critical role of YAP in the regulation of cellular senescence and provide a novel insight into a potential chemotherapeutic avenue for tumor suppression.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 143 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 3%
Canada 2 1%
Italy 1 <1%
China 1 <1%
France 1 <1%
Unknown 134 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 42 29%
Researcher 29 20%
Student > Master 17 12%
Student > Bachelor 10 7%
Student > Doctoral Student 6 4%
Other 21 15%
Unknown 18 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 47 33%
Biochemistry, Genetics and Molecular Biology 39 27%
Medicine and Dentistry 18 13%
Neuroscience 5 3%
Chemistry 3 2%
Other 7 5%
Unknown 24 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 April 2023.
All research outputs
#6,187,906
of 23,770,218 outputs
Outputs from Cancer Research
#6,608
of 18,486 outputs
Outputs of similar age
#50,364
of 198,690 outputs
Outputs of similar age from Cancer Research
#62
of 166 outputs
Altmetric has tracked 23,770,218 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 18,486 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 198,690 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 166 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.