| Title |
Coenzyme Q10 Depletion in Medical and Neuropsychiatric Disorders: Potential Repercussions and Therapeutic Implications
|
|---|---|
| Published in |
Molecular Neurobiology, June 2013
|
| DOI | 10.1007/s12035-013-8477-8 |
| Pubmed ID | |
| Authors |
Gerwyn Morris, George Anderson, Michael Berk, Michael Maes |
| Abstract |
Coenzyme Q10 (CoQ10) is an antioxidant, a membrane stabilizer, and a vital cofactor in the mitochondrial electron transport chain, enabling the generation of adenosine triphosphate. It additionally regulates gene expression and apoptosis; is an essential cofactor of uncoupling proteins; and has anti-inflammatory, redox modulatory, and neuroprotective effects. This paper reviews the known physiological role of CoQ10 in cellular metabolism, cell death, differentiation and gene regulation, and examines the potential repercussions of CoQ10 depletion including its role in illnesses such as Parkinson's disease, depression, myalgic encephalomyelitis/chronic fatigue syndrome, and fibromyalgia. CoQ10 depletion may play a role in the pathophysiology of these disorders by modulating cellular processes including hydrogen peroxide formation, gene regulation, cytoprotection, bioenegetic performance, and regulation of cellular metabolism. CoQ10 treatment improves quality of life in patients with Parkinson's disease and may play a role in delaying the progression of that disorder. Administration of CoQ10 has antidepressive effects. CoQ10 treatment significantly reduces fatigue and improves ergonomic performance during exercise and thus may have potential in alleviating the exercise intolerance and exhaustion displayed by people with myalgic encepholamyletis/chronic fatigue syndrome. Administration of CoQ10 improves hyperalgesia and quality of life in patients with fibromyalgia. The evidence base for the effectiveness of treatment with CoQ10 may be explained via its ability to ameliorate oxidative stress and protect mitochondria. |
X Demographics
The data shown below were collected from the profiles of 17 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 12% |
| United States | 2 | 12% |
| Ireland | 1 | 6% |
| Japan | 1 | 6% |
| Netherlands | 1 | 6% |
| Belgium | 1 | 6% |
| Unknown | 9 | 53% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 76% |
| Practitioners (doctors, other healthcare professionals) | 3 | 18% |
| Scientists | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 197 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 1% |
| Brazil | 1 | <1% |
| Australia | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 191 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 40 | 20% |
| Student > Master | 24 | 12% |
| Researcher | 23 | 12% |
| Other | 16 | 8% |
| Student > Ph. D. Student | 12 | 6% |
| Other | 30 | 15% |
| Unknown | 52 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 53 | 27% |
| Nursing and Health Professions | 17 | 9% |
| Agricultural and Biological Sciences | 14 | 7% |
| Psychology | 14 | 7% |
| Biochemistry, Genetics and Molecular Biology | 8 | 4% |
| Other | 37 | 19% |
| Unknown | 54 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 25. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 July 2018.
All research outputs
#1,572,441
of 25,654,806 outputs
Outputs from Molecular Neurobiology
#119
of 4,005 outputs
Outputs of similar age
#12,976
of 210,156 outputs
Outputs of similar age from Molecular Neurobiology
#3
of 25 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,005 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 210,156 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.