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Mendeley readers
Attention Score in Context
| Title |
Hydantoin based inhibitors of MMP13—Discovery of AZD6605
|
|---|---|
| Published in |
Bioorganic & Medicinal Chemistry Letters, June 2013
|
| DOI | 10.1016/j.bmcl.2013.05.089 |
| Pubmed ID | |
| Authors |
Chris De Savi, David Waterson, Andrew Pape, Scott Lamont, Elma Hadley, Mark Mills, Ken M. Page, Jonathan Bowyer, Rose A. Maciewicz |
| Abstract |
Piperidine ether and aryl piperazine hydantoins are reported as potent inhibitors of MMP13. A medicinal chemistry campaign focused on replacing the reverse hydroxamate zinc binding group associated with historical inhibitors with a hydantoin zinc binding group then optimising MMP13 potency, solubility and DMPK properties whilst maintaining good selectivity over MMP14. A number of high quality candidates were progressed and following rat and dog safety evaluation, AZD6605 (3m) was identified as a candidate drug. |
Mendeley readers
The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 5% |
| United Kingdom | 1 | 5% |
| Unknown | 19 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 24% |
| Student > Bachelor | 4 | 19% |
| Other | 3 | 14% |
| Student > Master | 3 | 14% |
| Student > Ph. D. Student | 2 | 10% |
| Other | 2 | 10% |
| Unknown | 2 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 12 | 57% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 19% |
| Biochemistry, Genetics and Molecular Biology | 2 | 10% |
| Unknown | 3 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 June 2013.
All research outputs
#17,285,036
of 25,371,288 outputs
Outputs from Bioorganic & Medicinal Chemistry Letters
#12,193
of 13,779 outputs
Outputs of similar age
#132,985
of 209,922 outputs
Outputs of similar age from Bioorganic & Medicinal Chemistry Letters
#100
of 111 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,779 research outputs from this source. They receive a mean Attention Score of 4.9. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 209,922 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 111 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.