| Title |
The role of genetic and epigenetic alterations in neuroblastoma disease pathogenesis
|
|---|---|
| Published in |
Pediatric Surgery International, December 2012
|
| DOI | 10.1007/s00383-012-3239-7 |
| Pubmed ID | |
| Authors |
Raquel Domingo-Fernandez, Karen Watters, Olga Piskareva, Raymond L. Stallings, Isabella Bray |
| Abstract |
Neuroblastoma is a highly heterogeneous tumor accounting for 15 % of all pediatric cancer deaths. Clinical behavior ranges from the spontaneous regression of localized, asymptomatic tumors, as well as metastasized tumors in infants, to rapid progression and resistance to therapy. Genomic amplification of the MYCN oncogene has been used to predict outcome in neuroblastoma for over 30 years, however, recent methodological advances including miRNA and mRNA profiling, comparative genomic hybridization (array-CGH), and whole-genome sequencing have enabled the detailed analysis of the neuroblastoma genome, leading to the identification of new prognostic markers and better patient stratification. In this review, we will describe the main genetic factors responsible for these diverse clinical phenotypes in neuroblastoma, the chronology of their discovery, and the impact on patient prognosis. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 1% |
| Norway | 1 | 1% |
| Belgium | 1 | 1% |
| Unknown | 93 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 17% |
| Student > Bachelor | 15 | 16% |
| Student > Master | 14 | 15% |
| Researcher | 11 | 11% |
| Student > Postgraduate | 7 | 7% |
| Other | 16 | 17% |
| Unknown | 17 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 25 | 26% |
| Medicine and Dentistry | 21 | 22% |
| Agricultural and Biological Sciences | 20 | 21% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Chemistry | 2 | 2% |
| Other | 6 | 6% |
| Unknown | 20 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 June 2013.
All research outputs
#16,170,857
of 23,853,707 outputs
Outputs from Pediatric Surgery International
#617
of 1,317 outputs
Outputs of similar age
#187,547
of 286,306 outputs
Outputs of similar age from Pediatric Surgery International
#13
of 18 outputs
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