| Title |
Tyrosine Kinase Inhibitors and Proton Pump Inhibitors: An Evaluation of Treatment Options
|
|---|---|
| Published in |
Clinical Pharmacokinetics, January 2017
|
| DOI | 10.1007/s40262-016-0503-3 |
| Pubmed ID | |
| Authors |
Roelof W. F. van Leeuwen, Frank G. A. Jansman, Nicole G. Hunfeld, Robert Peric, Anna K. L. Reyners, Alex L. T. Imholz, Jacobus R. B. J. Brouwers, Joachim G. Aerts, Teun van Gelder, Ron H. J. Mathijssen |
| Abstract |
Tyrosine kinase inhibitors (TKIs) have rapidly become an established factor in oncology, and have been shown to be effective in a wide variety of solid and hematologic malignancies. Use of the oral administration route of TKIs offers flexibility and is convenient for the patient; however, despite these advantages, the oral route of administration also causes a highly relevant new problem. Acid-inhibitory drugs, such as proton pump inhibitors (PPIs), increase the intragastric pH, which may subsequently decrease TKI solubility, bioavailability, and treatment efficacy. Clear and practical advice on how to manage PPI use during TKI therapy is currently not available in the literature. Since PPIs are extensively used during TKI therapy, prescribers are presented with a big dilemma as to whether or not to continue the combined treatment, resulting in patients possibly being deprived of optimal therapy. When all pharmacological characteristics and data of either TKIs and PPIs are considered, practical and safe advice on how to manage this drug combination can be given. |
X Demographics
The data shown below were collected from the profiles of 34 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 13 | 38% |
| France | 1 | 3% |
| Unknown | 20 | 59% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 19 | 56% |
| Practitioners (doctors, other healthcare professionals) | 13 | 38% |
| Scientists | 2 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 53 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 11% |
| Researcher | 6 | 11% |
| Student > Master | 6 | 11% |
| Student > Bachelor | 4 | 8% |
| Other | 4 | 8% |
| Other | 11 | 21% |
| Unknown | 16 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 16 | 30% |
| Medicine and Dentistry | 14 | 26% |
| Biochemistry, Genetics and Molecular Biology | 2 | 4% |
| Arts and Humanities | 1 | 2% |
| Business, Management and Accounting | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 18 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 February 2019.
All research outputs
#1,806,479
of 25,401,784 outputs
Outputs from Clinical Pharmacokinetics
#56
of 1,603 outputs
Outputs of similar age
#36,683
of 421,458 outputs
Outputs of similar age from Clinical Pharmacokinetics
#5
of 31 outputs
Altmetric has tracked 25,401,784 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,603 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 421,458 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.