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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Dynamic microtubules produce an asymmetric E-cadherin–Bazooka complex to maintain segment boundaries
|
|---|---|
| Published in |
Journal of Cell Biology, June 2013
|
| DOI | 10.1083/jcb.201211159 |
| Pubmed ID | |
| Authors |
Natalia A. Bulgakova, Ilya Grigoriev, Alpha S. Yap, Anna Akhmanova, Nicholas H. Brown |
| Abstract |
Distributing junctional components around the cell periphery is key for epithelial tissue morphogenesis and homeostasis. We discovered that positioning of dynamic microtubules controls the asymmetric accumulation of E-cadherin. Microtubules are oriented preferentially along the dorso-ventral axis in Drosophila melanogaster embryonic epidermal cells, and thus more frequently contact E-cadherin at dorso-ventral cell-cell borders. This inhibits RhoGEF2, reducing membrane recruitment of Rho-kinase, and increasing a specific E-cadherin pool that is mobile when assayed by fluorescence recovery after photobleaching. This mobile E-cadherin is complexed with Bazooka/Par-3, which in turn is required for normal levels of mobile E-cadherin. Mobile E-cadherin-Bazooka prevents formation of multicellular rosette structures and cell motility across the segment border in Drosophila embryos. Altogether, the combined action of dynamic microtubules and Rho signaling determines the level and asymmetric distribution of a mobile E-cadherin-Bazooka complex, which regulates cell behavior during the generation of a patterned epithelium. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Peru | 1 | 50% |
| United Kingdom | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 123 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 3 | 2% |
| Portugal | 3 | 2% |
| France | 2 | 2% |
| Netherlands | 1 | <1% |
| Unknown | 114 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 32 | 26% |
| Student > Ph. D. Student | 28 | 23% |
| Professor > Associate Professor | 12 | 10% |
| Student > Master | 9 | 7% |
| Professor | 8 | 7% |
| Other | 19 | 15% |
| Unknown | 15 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 59 | 48% |
| Biochemistry, Genetics and Molecular Biology | 30 | 24% |
| Medicine and Dentistry | 6 | 5% |
| Neuroscience | 3 | 2% |
| Physics and Astronomy | 3 | 2% |
| Other | 6 | 5% |
| Unknown | 16 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 June 2015.
All research outputs
#14,600,874
of 25,377,790 outputs
Outputs from Journal of Cell Biology
#10,077
of 11,939 outputs
Outputs of similar age
#110,282
of 209,925 outputs
Outputs of similar age from Journal of Cell Biology
#40
of 77 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,939 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 209,925 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 77 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.