Title |
The seroprevalence of antithyroid peroxidase antibodies in bipolar families and bipolar twins: results from two longitudinal studies
|
---|---|
Published in |
International Journal of Bipolar Disorders, January 2017
|
DOI | 10.1186/s40345-017-0070-z |
Pubmed ID | |
Authors |
G. Snijders, L. de Witte, E. Mesman, S. Kemner, R. Vonk, R. Brouwer, W. A. Nolen, H. A. Drexhage, M. H. J. Hillegers |
Abstract |
Previous studies of our group among bipolar offspring and bipolar twins showed significant higher prevalence's and levels of antithyroid peroxidase antibodies (TPO-Abs) in offspring and co-twins (without a mood disorder) compared to controls, suggesting that TPO-Abs might be considered as vulnerability factor (trait marker) for BD development. Here we elucidate, in the same cohorts, but now after 12- and 6-year follow-up, whether TPO-abs should be considered as a 'trait' marker for BD. The present study aims to investigate whether TPO-Abs (1) are stable over time, (2) are associated with lithium-exposure, (3) share a common genetic background with BD and are related to psychopathology. In bipolar offspring and twins, the prevalence of TPO-Abs is stable over time (r s = .72 p < .001 resp. r s = .82, p < .001) and not associated with lithium use. At follow-up, an increased prevalence of TPO-abs was again observed in bipolar offspring (10,4% versus 4%) and higher TPO-abs titers were still present in co-twins of bipolar cases compared to control twins [mean 1.06 IU/ml (SD .82) versus mean .82 IU/ml (SD .67)], although statistical significance was lost. Although our results show a trend toward an increased inherited risk of the co-occurrence of BD and thyroid autoimmunity, large-scale studies can only draw final conclusions. Nationwide epidemiological and GWAS studies reach such numbers and support the view of a possible common (autoimmune) etiology of severe mood disorders and chronic recurrent infections and autoimmunity, including thyroid autoimmunity. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 29 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 5 | 17% |
Researcher | 5 | 17% |
Student > Master | 4 | 14% |
Student > Ph. D. Student | 3 | 10% |
Student > Doctoral Student | 2 | 7% |
Other | 2 | 7% |
Unknown | 8 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 8 | 28% |
Psychology | 6 | 21% |
Neuroscience | 4 | 14% |
Nursing and Health Professions | 1 | 3% |
Unknown | 10 | 34% |