| Title |
The hypoxia-inducible factors: key transcriptional regulators of hypoxic responses
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, July 2003
|
| DOI | 10.1007/s00018-003-2370-y |
| Pubmed ID | |
| Authors |
C. P. Bracken, M. L. Whitelaw, D. J. Peet |
| Abstract |
Oxygen depravation in mammals leads to the transcriptional induction of a host of target genes to metabolically adapt to this deficiency, including erythropoietin and vascular endothelial growth factor. This response is primarily mediated by the hypoxia-inducible factors (HIFs) which are members of the basic-helix-loop-helix/Per-ARNT-Sim (bHLH/PAS) transcription factor family. The HIFs are primarily regulated via a two-step mechanism of HIF post-translational modification, increasing both protein stability and transactivation capacity. This review aims to summarise our current understanding of these processes, and discuss the important role of the HIFs in the pathophysiology of many human diseases. |
Mendeley readers
The data shown below were compiled from readership statistics for 116 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 3 | 3% |
| Unknown | 113 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 21% |
| Researcher | 20 | 17% |
| Student > Master | 18 | 16% |
| Student > Bachelor | 10 | 9% |
| Student > Doctoral Student | 7 | 6% |
| Other | 21 | 18% |
| Unknown | 16 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 38 | 33% |
| Medicine and Dentistry | 24 | 21% |
| Biochemistry, Genetics and Molecular Biology | 19 | 16% |
| Chemistry | 3 | 3% |
| Immunology and Microbiology | 2 | 2% |
| Other | 10 | 9% |
| Unknown | 20 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 September 2016.
All research outputs
#7,845,540
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#1,655
of 4,151 outputs
Outputs of similar age
#17,168
of 49,587 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#12
of 28 outputs
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So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
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We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.