| Title |
Transient Receptor Potential Channels
|
|---|---|
| Published by |
Advances in experimental medicine and biology, January 2011
|
| DOI | 10.1007/978-94-007-0265-3 |
| Pubmed ID | |
| ISBNs |
978-9-40-070264-6, 978-9-40-070265-3, 978-9-40-177832-9
|
| Authors |
Islam, Md. Shahidul |
| Editors |
Md. Shahidul Islam |
| Abstract |
The liver plays a central role in whole body homeostasis by mediating the metabolism of carbohydrates, fats, proteins, drugs and xenobiotic compounds, and bile acid and protein secretion. Hepatocytes together with endothelial cells, Kupffer cells, smooth muscle cells, stellate and oval cells comprise the functioning liver. Many members of the TRP family of proteins are expressed in hepatocytes. However, knowledge of their cellular functions is limited. There is some evidence which suggests the involvement of TRPC1 in volume control, TRPV1 and V4 in cell migration, TRPC6 and TRPM7 in cell proliferation, and TRPPM in lysosomal Ca(2+) release. Altered expression of some TRP proteins, including TRPC6, TRPM2 and TRPV1, in tumorigenic cell lines may play roles in the development and progression of hepatocellular carcinoma and metastatic liver cancers. It is likely that future experiments will define important roles for other TRP proteins in the cellular functions of hepatocytes and other cell types of which the liver is composed. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 29% |
| Japan | 3 | 21% |
| Italy | 1 | 7% |
| Unknown | 6 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 93% |
| Scientists | 1 | 7% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 48 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 4 | 8% |
| Student > Master | 4 | 8% |
| Researcher | 4 | 8% |
| Professor > Associate Professor | 3 | 6% |
| Student > Ph. D. Student | 3 | 6% |
| Other | 3 | 6% |
| Unknown | 27 | 56% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 17% |
| Biochemistry, Genetics and Molecular Biology | 5 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
| Medicine and Dentistry | 3 | 6% |
| Social Sciences | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 27 | 56% |