| Title |
In vivo non-invasive serial monitoring of FDG-PET progression and regression in a rabbit model of atherosclerosis
|
|---|---|
| Published in |
The International Journal of Cardiovascular Imaging, November 2008
|
| DOI | 10.1007/s10554-008-9377-2 |
| Pubmed ID | |
| Authors |
Stephen G. Worthley, Zhuang Y. Zhang, Josef Machac, Gérard Helft, Cheuk Tang, Gary Y. H. Liew, Azfar G. Zaman, Matthew I. Worthley, Zahi A. Fayad, Monte S. Buchsbaum, Valentin Fuster, Juan J. Badimon |
| Abstract |
We investigated the ability of fluorodeoxyglucose positron emission tomography (FDG PET) imaging to serially monitor macrophage content in a rabbit model of atherosclerosis. Atherosclerosis was induced in rabbits (n = 8) by a combination of atherogenic diet and balloon denudation of the aorta. At the end of nine months, the rabbits were randomized to a further six months of the same atherogenic diet (progression group) or normal diet (regression group). In vivo uptake of FDG by the thoracic aorta was measured using aortic uptake-to-blood radioactivity ratios at the start and end of the randomized period. A significant increase in FDG uptake of the progression group after continued cholesterol feeding (aortic uptake-to-blood radioactivity: 0.57 +/- 0.02 to 0.68 +/- 0.02, P = 0.001), and a corresponding fall in FDG uptake of the regression group after returning to a normal chow diet (aortic uptake-to-blood radioactivity ratios: 0.67 +/- 0.02 to 0.53 +/- 0.02, P < 0.0001). FDG PET can quantify in vivo macrophage content and serially monitor changes in FDG activity in this rabbit model. |
Mendeley readers
The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 4% |
| Unknown | 25 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 23% |
| Student > Doctoral Student | 5 | 19% |
| Unspecified | 5 | 19% |
| Professor | 4 | 15% |
| Researcher | 3 | 12% |
| Other | 3 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 13 | 50% |
| Unspecified | 5 | 19% |
| Engineering | 3 | 12% |
| Agricultural and Biological Sciences | 2 | 8% |
| Biochemistry, Genetics and Molecular Biology | 2 | 8% |
| Other | 1 | 4% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 May 2013.
All research outputs
#8,534,976
of 25,373,627 outputs
Outputs from The International Journal of Cardiovascular Imaging
#351
of 2,012 outputs
Outputs of similar age
#37,391
of 105,276 outputs
Outputs of similar age from The International Journal of Cardiovascular Imaging
#1
of 2 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,012 research outputs from this source. They receive a mean Attention Score of 2.3. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 105,276 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them