Title |
Mechanisms of Regulatory B cell Function in Autoimmune and Inflammatory Diseases beyond IL-10
|
---|---|
Published in |
Journal of Clinical Medicine, January 2017
|
DOI | 10.3390/jcm6010012 |
Pubmed ID | |
Authors |
Avijit Ray, Bonnie N. Dittel |
Abstract |
In the past two decades it has become clear that in addition to antigen presentation and antibody production B cells play prominent roles in immune regulation. While B cell-derived IL-10 has garnered much attention, B cells also effectively regulate inflammation by a variety of IL-10-independent mechanisms. B cell regulation has been studied in both autoimmune and inflammatory diseases. While collectively called regulatory B cells (Breg), no definitive phenotype has emerged for B cells with regulatory potential. This has made their study challenging and thus unique B cell regulatory mechanisms have emerged in a disease-dependent manner. Thus to harness the therapeutic potential of Breg, further studies are needed to understand how they emerge and are induced to evoke their regulatory activities. |
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Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 33% |
United States | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
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Unknown | 92 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 16 | 17% |
Student > Bachelor | 16 | 17% |
Student > Ph. D. Student | 14 | 15% |
Researcher | 10 | 11% |
Other | 7 | 8% |
Other | 9 | 10% |
Unknown | 20 | 22% |
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Neuroscience | 4 | 4% |
Other | 2 | 2% |
Unknown | 27 | 29% |