| Title |
Functional Impairment of Bone Formation in the Pathogenesis of Osteoporosis: The Bone Marrow Regenerative Competence
|
|---|---|
| Published in |
Current Osteoporosis Reports, March 2013
|
| DOI | 10.1007/s11914-013-0139-2 |
| Pubmed ID | |
| Authors |
Joseph P. Bidwell, Marta B. Alvarez, Mark Hood, Paul Childress |
| Abstract |
The skeleton is a high-renewal organ that undergoes ongoing cycles of remodeling. The regenerative bone formation arm ultimately declines in the aging, postmenopausal skeleton, but current therapies do not adequately address this deficit. Bone marrow is the primary source of the skeletal anabolic response and the mesenchymal stem cells (MSCs), which give rise to bone matrix-producing osteoblasts. The identity of these stem cells is emerging, but it now appears that the term 'MSC' has often been misapplied to the bone marrow stromal cell (BMSC), a progeny of the MSC. Nevertheless, the changes in BMSC phenotype associated with age and estrogen depletion likely contribute to the attenuated regenerative competence of the marrow and may reflect alterations in MSC phenotype. Here we summarize current concepts in bone marrow MSC identity, and within this context, review recent observations on changes in bone marrow population dynamics associated with aging and menopause. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 3% |
| Brazil | 1 | 3% |
| Unknown | 33 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 7 | 20% |
| Student > Ph. D. Student | 5 | 14% |
| Student > Postgraduate | 4 | 11% |
| Student > Doctoral Student | 3 | 9% |
| Professor | 3 | 9% |
| Other | 8 | 23% |
| Unknown | 5 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 31% |
| Agricultural and Biological Sciences | 7 | 20% |
| Biochemistry, Genetics and Molecular Biology | 3 | 9% |
| Engineering | 2 | 6% |
| Sports and Recreations | 2 | 6% |
| Other | 4 | 11% |
| Unknown | 6 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 June 2013.
All research outputs
#20,195,024
of 22,712,476 outputs
Outputs from Current Osteoporosis Reports
#466
of 543 outputs
Outputs of similar age
#171,414
of 195,232 outputs
Outputs of similar age from Current Osteoporosis Reports
#5
of 6 outputs
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