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3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets

Overview of attention for article published in Genome Medicine, January 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

blogs
1 blog
twitter
94 X users
googleplus
1 Google+ user

Citations

dimensions_citation
177 Dimensions

Readers on

mendeley
212 Mendeley
citeulike
7 CiteULike
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Title
3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets
Published in
Genome Medicine, January 2017
DOI 10.1186/s13073-016-0393-x
Pubmed ID
Authors

Jianjiong Gao, Matthew T. Chang, Hannah C. Johnsen, Sizhi Paul Gao, Brooke E. Sylvester, Selcuk Onur Sumer, Hongxin Zhang, David B. Solit, Barry S. Taylor, Nikolaus Schultz, Chris Sander

Abstract

Many mutations in cancer are of unknown functional significance. Standard methods use statistically significant recurrence of mutations in tumor samples as an indicator of functional impact. We extend such analyses into the long tail of rare mutations by considering recurrence of mutations in clusters of spatially close residues in protein structures. Analyzing 10,000 tumor exomes, we identify more than 3000 rarely mutated residues in proteins as potentially functional and experimentally validate several in RAC1 and MAP2K1. These potential driver mutations (web resources: 3dhotspots.org and cBioPortal.org) can extend the scope of genomically informed clinical trials and of personalized choice of therapy.

X Demographics

X Demographics

The data shown below were collected from the profiles of 94 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 212 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 <1%
United Kingdom 1 <1%
Sweden 1 <1%
Australia 1 <1%
Unknown 207 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 53 25%
Researcher 42 20%
Student > Master 23 11%
Student > Bachelor 18 8%
Other 15 7%
Other 30 14%
Unknown 31 15%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 68 32%
Agricultural and Biological Sciences 48 23%
Medicine and Dentistry 19 9%
Computer Science 15 7%
Nursing and Health Professions 4 2%
Other 20 9%
Unknown 38 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 63. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 August 2023.
All research outputs
#646,394
of 24,525,936 outputs
Outputs from Genome Medicine
#124
of 1,513 outputs
Outputs of similar age
#14,513
of 427,644 outputs
Outputs of similar age from Genome Medicine
#5
of 32 outputs
Altmetric has tracked 24,525,936 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,513 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.1. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 427,644 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.