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Mendeley readers
Attention Score in Context
| Title |
Loss of the anaphase-promoting complex in quiescent cells causes unscheduled hepatocyte proliferation
|
|---|---|
| Published in |
Genes & Development, January 2004
|
| DOI | 10.1101/gad.285404 |
| Pubmed ID | |
| Authors |
Karin G Wirth, Romeo Ricci, Juan F Giménez-Abián, Shahryar Taghybeeglu, Nobuaki R Kudo, Wolfram Jochum, Mireille Vasseur-Cognet, Kim Nasmyth |
| Abstract |
The anaphase-promoting complex or cyclosome (APC/C) is an ubiquitin protein ligase that together with Cdc20 and Cdh1 targets mitotic proteins for degradation by the proteosome. APC-Cdc20 activity during mitosis triggers anaphase by destroying securin and cyclins. APC-Cdh1 promotes degradation of cyclins and other proteins during G(1). We show that loss of APC/C during embryogenesis is early lethal before embryonic day E6.5 (E6.5). To investigate the role of APC/C in quiescent cells, we conditionally inactivated the subunit Apc2 in mice. Deletion of Apc2 in quiescent hepatocytes caused re-entry into the cell cycle and arrest in metaphase, resulting in liver failure. Re-entry into the cell cycle either occurred without any proliferative stimulus or could be easily induced. We demonstrate that the APC has an additional function to prevent hepatocytes from unscheduled re-entry into the cell cycle. |
Mendeley readers
The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 3% |
| United Kingdom | 2 | 2% |
| Unknown | 85 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 28% |
| Researcher | 24 | 27% |
| Student > Bachelor | 8 | 9% |
| Student > Master | 6 | 7% |
| Professor > Associate Professor | 5 | 6% |
| Other | 13 | 14% |
| Unknown | 9 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 51 | 57% |
| Biochemistry, Genetics and Molecular Biology | 24 | 27% |
| Medicine and Dentistry | 3 | 3% |
| Mathematics | 1 | 1% |
| Social Sciences | 1 | 1% |
| Other | 1 | 1% |
| Unknown | 9 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 May 2021.
All research outputs
#1,989,894
of 22,712,476 outputs
Outputs from Genes & Development
#526
of 5,834 outputs
Outputs of similar age
#4,583
of 132,905 outputs
Outputs of similar age from Genes & Development
#2
of 33 outputs
Altmetric has tracked 22,712,476 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,834 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 132,905 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.