Title |
Regrow or Repair: Potential Regenerative Therapies for the Kidney
|
---|---|
Published in |
Journal of the American Society of Nephrology, July 2006
|
DOI | 10.1681/asn.2006030218 |
Pubmed ID | |
Authors |
Melissa H. Little |
Abstract |
Regenerative medicine is being heralded in a similar way as gene therapy was some 15 yr ago. It is an area of intense excitement and potential, as well as myth and disinformation. However, with the increasing rate of end-stage renal failure and limited alternatives for its treatment, we must begin to investigate seriously potential regenerative approaches for the kidney. This review defines which regenerative options there might be for renal disease, summarizes the progress that has been made to date, and investigates some of the unique obstacles to such treatments that the kidney presents. The options discussed include in situ organ repair via bone marrow recruitment or dedifferentiation; ex vivo stem cell therapies, including both autologous and nonautologous options; and bioengineering approaches for the creation of a replacement organ. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 2% |
Indonesia | 1 | <1% |
Germany | 1 | <1% |
Iran, Islamic Republic of | 1 | <1% |
Australia | 1 | <1% |
Unknown | 105 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 28 | 25% |
Researcher | 21 | 19% |
Student > Bachelor | 14 | 13% |
Student > Master | 10 | 9% |
Other | 9 | 8% |
Other | 19 | 17% |
Unknown | 10 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 40 | 36% |
Medicine and Dentistry | 22 | 20% |
Biochemistry, Genetics and Molecular Biology | 21 | 19% |
Engineering | 6 | 5% |
Materials Science | 2 | 2% |
Other | 10 | 9% |
Unknown | 10 | 9% |