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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
|
|---|---|
| Published in |
Blood, November 2002
|
| DOI | 10.1182/blood-2002-10-3235 |
| Pubmed ID | |
| Authors |
Elizabeta Nemeth, Erika V. Valore, Mary Territo, Gary Schiller, Alan Lichtenstein, Tomas Ganz |
| Abstract |
Hepcidin is a liver-made peptide proposed to be a central regulator of intestinal iron absorption and iron recycling by macrophages. In animal models, hepcidin is induced by inflammation and iron loading, but its regulation in humans has not been studied. We report that urinary excretion of hepcidin was greatly increased in patients with iron overload, infections, or inflammatory diseases. Hepcidin excretion correlated well with serum ferritin levels, which are regulated by similar pathologic stimuli. In vitro iron loading of primary human hepatocytes, however, unexpectedly down-regulated hepcidin mRNA, suggesting that in vivo regulation of hepcidin expression by iron stores involves complex indirect effects. Hepcidin mRNA was dramatically induced by interleukin-6 (IL-6) in vitro, but not by IL-1 or tumor necrosis factor alpha (TNF-alpha), demonstrating that human hepcidin is a type II acute-phase reactant. The linkage of hepcidin induction to inflammation in humans supports its proposed role as a key mediator of anemia of inflammation. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 373 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| Japan | 2 | <1% |
| Australia | 1 | <1% |
| India | 1 | <1% |
| Egypt | 1 | <1% |
| Germany | 1 | <1% |
| Canada | 1 | <1% |
| Mexico | 1 | <1% |
| Unknown | 363 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 57 | 15% |
| Researcher | 46 | 12% |
| Student > Master | 45 | 12% |
| Student > Bachelor | 35 | 9% |
| Student > Doctoral Student | 30 | 8% |
| Other | 92 | 25% |
| Unknown | 68 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 107 | 29% |
| Agricultural and Biological Sciences | 80 | 21% |
| Biochemistry, Genetics and Molecular Biology | 48 | 13% |
| Immunology and Microbiology | 15 | 4% |
| Nursing and Health Professions | 7 | 2% |
| Other | 39 | 10% |
| Unknown | 77 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 June 2023.
All research outputs
#2,202,253
of 25,374,917 outputs
Outputs from Blood
#2,226
of 33,238 outputs
Outputs of similar age
#2,655
of 55,534 outputs
Outputs of similar age from Blood
#6
of 282 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 33,238 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 55,534 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 282 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.