| Title |
Nephroprotective action of sirtuin 1 (SIRT1)
|
|---|---|
| Published in |
Journal of Physiology and Biochemistry, June 2013
|
| DOI | 10.1007/s13105-013-0268-1 |
| Pubmed ID | |
| Authors |
Dorota Polak-Jonkisz, Krystyna Laszki-Szcząchor, Leopold Rehan, Witold Pilecki, Henryk Filipowski, Małgorzata Sobieszczańska |
| Abstract |
Sirtuins, silent information regulator 2 (Sir 2) proteins, belong to the family of NAD(+)-dependent enzymes with deacetylase or mono-ADP-ribosyltransferase activity. These enzymes are responsible for processes of DNA repair or recombination, chromosomal stability and gene transcription. In mammals, sirtuins occur in seven varieties, from 1 to 7 (SIRT1-SIRT7), differing among themselves with location. SIRT1, the best known variety, exerts its effects on proteins via NAD(+) coenzymes, being thus associated with cellular energetic metabolism and the 'red-ox' state. Its deficits are, among others, concomitant with stressful situations and associated with pathophysiologies of many medical conditions, including diabetes mellitus, cardiovascular diseases, neurodegenerative syndromes and kidney diseases. In kidney disorders, it promotes (stimulates) the survival of cells in an affected kidney by modulating their responses to various stress stimuli, takes part in arterial blood pressure control, protects against cellular apoptosis in renal tubules by catalase induction and triggers autophagy. More and more available in vitro and in vivo data indicate SIRT1 activity to be oriented, among others, towards nephroprotection. Thus, SIRT1 may become a novel element in the therapy of age-related renal diseases, including diabetic nephropathy. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 36 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 5 | 14% |
| Researcher | 4 | 11% |
| Student > Ph. D. Student | 4 | 11% |
| Professor | 4 | 11% |
| Student > Bachelor | 2 | 6% |
| Other | 10 | 28% |
| Unknown | 7 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 9 | 25% |
| Medicine and Dentistry | 8 | 22% |
| Biochemistry, Genetics and Molecular Biology | 5 | 14% |
| Immunology and Microbiology | 2 | 6% |
| Neuroscience | 1 | 3% |
| Other | 2 | 6% |
| Unknown | 9 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 June 2013.
All research outputs
#18,340,605
of 22,712,476 outputs
Outputs from Journal of Physiology and Biochemistry
#404
of 527 outputs
Outputs of similar age
#147,631
of 196,666 outputs
Outputs of similar age from Journal of Physiology and Biochemistry
#8
of 10 outputs
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So far Altmetric has tracked 527 research outputs from this source. They receive a mean Attention Score of 4.1. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
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