| Title |
The cancer chemopreventive actions of phytochemicals derived from glucosinolates
|
|---|---|
| Published in |
European Journal of Nutrition, May 2008
|
| DOI | 10.1007/s00394-008-2009-8 |
| Pubmed ID | |
| Authors |
John D. Hayes, Michael O. Kelleher, Ian M. Eggleston |
| Abstract |
This article reviews the mechanisms by which glucosinolate breakdown products are thought to inhibit carcinogenesis. It describes how isothiocyanates, thiocyanates, nitriles, cyano-epithioalkanes and indoles are produced from glucosinolates through the actions of myrosinase, epithiospecifier protein and epithiospecifier modifier protein released from cruciferous vegetables during injury to the plant. The various biological activities displayed by these phytochemicals are described. In particular, their abilities to induce cytoprotective genes, mediated by the Nrf2 (NF-E2 related factor 2) and AhR (arylhydrocarbon receptor) transcription factors, and their abilities to repress NF-kappaB (nuclear factor-kappaB) activity, inhibit histone deacetylase, and inhibit cytochrome P450 are outlined. Isothiocyanates appear to alter gene expression through modification of critical thiols in regulatory proteins such as Keap1 (Kelch-like ECH-associated protein 1) or IKK (IkappaB kinase), causing activation of Nrf2 and inactivation of NF-kappaB, respectively. Certain indoles act as ligands for AhR. Isothiocyanates and indoles are also capable of affecting cell cycle arrest and stimulating apoptosis. The mechanisms responsible for these anti-proliferative responses are discussed. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 40% |
| Thailand | 1 | 10% |
| Unknown | 5 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 90% |
| Practitioners (doctors, other healthcare professionals) | 1 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 223 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 2 | <1% |
| Malaysia | 1 | <1% |
| France | 1 | <1% |
| Belgium | 1 | <1% |
| Denmark | 1 | <1% |
| Lebanon | 1 | <1% |
| Serbia | 1 | <1% |
| Unknown | 215 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 43 | 19% |
| Student > Master | 38 | 17% |
| Student > Bachelor | 24 | 11% |
| Researcher | 20 | 9% |
| Student > Doctoral Student | 11 | 5% |
| Other | 39 | 17% |
| Unknown | 48 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 75 | 34% |
| Biochemistry, Genetics and Molecular Biology | 26 | 12% |
| Medicine and Dentistry | 18 | 8% |
| Chemistry | 14 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 3% |
| Other | 25 | 11% |
| Unknown | 59 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 79. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 October 2023.
All research outputs
#513,772
of 24,643,522 outputs
Outputs from European Journal of Nutrition
#138
of 2,539 outputs
Outputs of similar age
#852
of 81,711 outputs
Outputs of similar age from European Journal of Nutrition
#1
of 11 outputs
Altmetric has tracked 24,643,522 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,539 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.6. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 81,711 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.