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Mendeley readers
Attention Score in Context
| Title |
Mutant prion proteins in Gerstmann-Sträussler-Scheinker disease with neurofibrillary tangles
|
|---|---|
| Published in |
Nature Genetics, April 1992
|
| DOI | 10.1038/ng0492-68 |
| Pubmed ID | |
| Authors |
Karen Hsiao, Stephen R. Dlouhy, Martin R. Farlow, Carin Cass, Maria Da Costa, P. Michael Conneally, M. E. Hodes, Bernardino Ghetti, Stanley B. Prusiner |
| Abstract |
Two families with Gerstmann-Sträussler-Scheinker disease (GSS) are atypical in possessing neocortical neurofibrillary tangles (NFTs), which are few or absent in other kindreds with GSS, in addition to amyloid plaques that react with prion protein (PrP) antibodies and protease-resistant PrP accumulation in the brain. A leucine substitution at PrP codon 102 has been genetically linked to GSS in some families. We examined the PrP gene in these families. A serine for phenylalanine substitution was found at codon 198 in the Indiana patients; arginine for glutamine substitution at codon 217 in the Swedish patients. These mutations in PrP are the first to be associated with the appearance of both PrP amyloid plaques and neocortical NFTs in GSS patients. |
Mendeley readers
The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Unknown | 58 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 19% |
| Student > Ph. D. Student | 9 | 15% |
| Professor | 6 | 10% |
| Student > Bachelor | 5 | 8% |
| Student > Master | 4 | 7% |
| Other | 12 | 20% |
| Unknown | 12 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 16 | 27% |
| Neuroscience | 8 | 14% |
| Agricultural and Biological Sciences | 7 | 12% |
| Medicine and Dentistry | 5 | 8% |
| Chemistry | 4 | 7% |
| Other | 6 | 10% |
| Unknown | 13 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 April 2017.
All research outputs
#5,925,470
of 22,947,506 outputs
Outputs from Nature Genetics
#5,016
of 7,217 outputs
Outputs of similar age
#5,044
of 19,387 outputs
Outputs of similar age from Nature Genetics
#15
of 25 outputs
Altmetric has tracked 22,947,506 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 7,217 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 41.3. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 19,387 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.