| Title |
Microglia Activation and Anti-inflammatory Regulation in Alzheimer’s Disease
|
|---|---|
| Published in |
Molecular Neurobiology, March 2010
|
| DOI | 10.1007/s12035-010-8106-8 |
| Pubmed ID | |
| Authors |
Lih-Fen Lue, Yu-Min Kuo, Thomas Beach, Douglas G. Walker |
| Abstract |
Inflammatory regulators, including endogenous anti-inflammatory systems, can down-regulate inflammation thus providing negative feedback. Chronic inflammation can result from imbalance between levels of inflammatory mediators and regulators during immune responses. As a consequence, there are heightened inflammatory responses and irreversible tissue damage associated with many age-related chronic diseases. Alzheimer's disease (AD) brain is marked by prominent inflammatory features, in which microglial activation is the driving force for the elaboration of an inflammatory cascade. How the regulation of inflammation loses its effectiveness during AD pathogenesis remains largely unclear. In this article, we will first review current knowledge of microglial activation and its association with AD pathology. We then discuss four examples of anti-inflammatory systems that could play a role in regulating microglial activation: CD200/CD200 receptor, vitamin D receptor, peroxisome proliferator-activated receptors, and soluble receptor for advanced glycation end products. Through this, we hope to illustrate the diverse aspects of inflammatory regulatory systems in brain and neurodegenerative diseases such as AD. We also propose the importance of neuronal defense systems, because they are part of the integral inflammatory and anti-inflammatory systems. Augmenting the anti-inflammatory defenses of neurons can be included in the strategy for restoration of balanced immune responses during aging and neurodegenerative diseases. |
Mendeley readers
The data shown below were compiled from readership statistics for 162 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 1% |
| Chile | 1 | <1% |
| Germany | 1 | <1% |
| France | 1 | <1% |
| Unknown | 157 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 27 | 17% |
| Student > Ph. D. Student | 26 | 16% |
| Student > Bachelor | 26 | 16% |
| Student > Master | 19 | 12% |
| Student > Doctoral Student | 9 | 6% |
| Other | 27 | 17% |
| Unknown | 28 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 37 | 23% |
| Medicine and Dentistry | 31 | 19% |
| Neuroscience | 17 | 10% |
| Biochemistry, Genetics and Molecular Biology | 12 | 7% |
| Immunology and Microbiology | 6 | 4% |
| Other | 21 | 13% |
| Unknown | 38 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 July 2022.
All research outputs
#2,888,731
of 22,880,230 outputs
Outputs from Molecular Neurobiology
#430
of 3,467 outputs
Outputs of similar age
#11,396
of 93,608 outputs
Outputs of similar age from Molecular Neurobiology
#2
of 12 outputs
Altmetric has tracked 22,880,230 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,467 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 93,608 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.