| Title |
A placebo-controlled study of sildenafil effects on cognition in schizophrenia
|
|---|---|
| Published in |
Psychopharmacology, August 2008
|
| DOI | 10.1007/s00213-008-1278-5 |
| Pubmed ID | |
| Authors |
Donald C. Goff, Corinne Cather, Oliver Freudenreich, David C. Henderson, A. Eden Evins, Melissa A. Culhane, Jared P. Walsh |
| Abstract |
Phosphodiesterase 5 (PDE5) inhibitors increase cyclic guanosine monophosphate (cGMP) concentrations in the intracellular pathway activated by N-methyl-D-aspartic acid receptors which is believed to mediate long-term potentiation and memory consolidation. The PDE5 inhibitor sildenafil has been shown to enhance memory in animal models. In addition, neuronal nitric oxide synthase, another component of the NMDA/nitric oxide/cGMP intracellular pathway, has been reported to be dysregulated in schizophrenia patients. |
Mendeley readers
The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 1% |
| Unknown | 92 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 21 | 23% |
| Student > Master | 13 | 14% |
| Student > Ph. D. Student | 12 | 13% |
| Student > Bachelor | 10 | 11% |
| Other | 9 | 10% |
| Other | 16 | 17% |
| Unknown | 12 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 21 | 23% |
| Psychology | 17 | 18% |
| Neuroscience | 9 | 10% |
| Biochemistry, Genetics and Molecular Biology | 5 | 5% |
| Agricultural and Biological Sciences | 5 | 5% |
| Other | 19 | 20% |
| Unknown | 17 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 November 2012.
All research outputs
#20,195,024
of 22,712,476 outputs
Outputs from Psychopharmacology
#4,927
of 5,335 outputs
Outputs of similar age
#80,203
of 83,512 outputs
Outputs of similar age from Psychopharmacology
#32
of 35 outputs
Altmetric has tracked 22,712,476 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,335 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.