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X Demographics
Mendeley readers
Attention Score in Context
| Title |
VEGF significantly restores impaired memory behavior in Alzheimer's mice by improvement of vascular survival
|
|---|---|
| Published in |
Scientific Reports, June 2013
|
| DOI | 10.1038/srep02053 |
| Pubmed ID | |
| Authors |
Piotr Religa, Renhai Cao, Dorota Religa, Yuan Xue, Nenad Bogdanovic, David Westaway, Hugo H. Marti, Bengt Winblad, Yihai Cao |
| Abstract |
The functional impact of amyloid peptides (Aβs) on the vascular system is less understood despite these pathologic peptides are substantially deposited in the brain vasculature of Alzheimer's patients. Here we show substantial accumulation of Aβs 40 and 42 in the brain arterioles of Alzheimer's patients and of transgenic Alzheimer's mice. Purified Aβs 1-40 and 1-42 exhibited vascular regression activity in the in vivo animal models and vessel density was reversely correlated with numbers and sizes of amyloid plaques in human patients. A significant high number of vascular cells underwent cellular apoptosis in the brain vasculature of Alzheimer's patients. VEGF significantly prevented Aβ-induced endothelial apoptosis in vitro. Neuronal expression of VEGF in transgenic mice restored memory behavior of Alzheimer's. These findings provide conceptual implication of improvement of vascular functions as a novel therapeutic approach for the treatment of Alzheimer's disease. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 20% |
| Netherlands | 1 | 20% |
| Spain | 1 | 20% |
| Italy | 1 | 20% |
| Unknown | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Germany | 1 | <1% |
| Switzerland | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 106 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 22% |
| Researcher | 18 | 16% |
| Student > Bachelor | 13 | 12% |
| Student > Master | 11 | 10% |
| Professor | 10 | 9% |
| Other | 13 | 12% |
| Unknown | 21 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 23 | 21% |
| Neuroscience | 17 | 15% |
| Biochemistry, Genetics and Molecular Biology | 15 | 14% |
| Medicine and Dentistry | 15 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
| Other | 9 | 8% |
| Unknown | 27 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 April 2021.
All research outputs
#5,428,589
of 22,712,476 outputs
Outputs from Scientific Reports
#36,871
of 122,405 outputs
Outputs of similar age
#45,332
of 196,543 outputs
Outputs of similar age from Scientific Reports
#152
of 513 outputs
Altmetric has tracked 22,712,476 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 122,405 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 196,543 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 513 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.