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X Demographics
Mendeley readers
Attention Score in Context
| Title |
CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer
|
|---|---|
| Published in |
Genome Research, June 2013
|
| DOI | 10.1101/gr.152942.112 |
| Pubmed ID | |
| Authors |
Hui Ling, Riccardo Spizzo, Yaser Atlasi, Milena Nicoloso, Masayoshi Shimizu, Roxana S. Redis, Naohiro Nishida, Roberta Gafà, Jian Song, Zhiyi Guo, Cristina Ivan, Elisa Barbarotto, Ingrid De Vries, Xinna Zhang, Manuela Ferracin, Mike Churchman, Janneke F. van Galen, Berna H. Beverloo, Maryam Shariati, Franziska Haderk, Marcos R. Estecio, Guillermo Garcia-Manero, Gijs A. Patijn, David C. Gotley, Vikas Bhardwaj, Imad Shureiqi, Subrata Sen, Asha S. Multani, James Welsh, Ken Yamamoto, Itsuki Taniguchi, Min-Ae Song, Steven Gallinger, Graham Casey, Stephen N. Thibodeau, Loïc Le Marchand, Maarit Tiirikainen, Sendurai A. Mani, Wei Zhang, Ramana V. Davuluri, Koshi Mimori, Masaki Mori, Anieta M. Sieuwerts, John W.M. Martens, Ian Tomlinson, Massimo Negrini, Ioana Berindan-Neagoe, John A. Foekens, Stanley R. Hamilton, Giovanni Lanza, Scott Kopetz, Riccardo Fodde, George A. Calin |
| Abstract |
The functional roles of SNPs within the 8q24 gene desert in the cancer phenotype are not yet well understood. Here, we report that CCAT2, a novel long noncoding RNA transcript (lncRNA) encompassing the rs6983267 SNP, is highly overexpressed in microsatellite-stable colorectal cancer and promotes tumor growth, metastasis, and chromosomal instability. We demonstrate that MYC, miR-17-5p, and miR-20a are up-regulated by CCAT2 through TCF7L2-mediated transcriptional regulation. We further identify the physical interaction between CCAT2 and TCF7L2 resulting in an enhancement of WNT signaling activity. We show that CCAT2 is itself a WNT downstream target, which suggests the existence of a feedback loop. Finally, we demonstrate that the SNP status affects CCAT2 expression and the risk allele G produces more CCAT2 transcript. Our results support a new mechanism of MYC and WNT regulation by the novel lncRNA CCAT2 in colorectal cancer pathogenesis, and provide an alternative explanation of the SNP-conferred cancer risk. |
X Demographics
The data shown below were collected from the profiles of 15 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 53% |
| Peru | 1 | 7% |
| United Kingdom | 1 | 7% |
| France | 1 | 7% |
| Unknown | 4 | 27% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 9 | 60% |
| Members of the public | 5 | 33% |
| Science communicators (journalists, bloggers, editors) | 1 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 261 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | <1% |
| Hong Kong | 1 | <1% |
| Austria | 1 | <1% |
| United Kingdom | 1 | <1% |
| Belgium | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 254 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 50 | 19% |
| Researcher | 47 | 18% |
| Student > Master | 47 | 18% |
| Student > Doctoral Student | 16 | 6% |
| Student > Bachelor | 16 | 6% |
| Other | 38 | 15% |
| Unknown | 47 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 80 | 31% |
| Agricultural and Biological Sciences | 71 | 27% |
| Medicine and Dentistry | 29 | 11% |
| Business, Management and Accounting | 2 | <1% |
| Chemistry | 2 | <1% |
| Other | 19 | 7% |
| Unknown | 58 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 June 2023.
All research outputs
#2,827,941
of 25,374,647 outputs
Outputs from Genome Research
#1,398
of 4,425 outputs
Outputs of similar age
#23,877
of 209,149 outputs
Outputs of similar age from Genome Research
#24
of 50 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,425 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.3. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 209,149 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 50 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.