| Title |
Development of Probiotic Tablets Using Microparticles: Viability Studies and Stability Studies
|
|---|---|
| Published in |
AAPS PharmSciTech, December 2012
|
| DOI | 10.1208/s12249-012-9898-9 |
| Pubmed ID | |
| Authors |
J. P. Sousa e Silva, Sérgio C. Sousa, Paulo Costa, Emília Cerdeira, Maria H. Amaral, José Sousa Lobo, Ana M. Gomes, Maria M. Pintado, Dina Rodrigues, Teresa Rocha-Santos, Ana C. Freitas |
| Abstract |
Alternative vectors to deliver viable cells of probiotics, to those conferring limited resistance to gastrointestinal conditions, still need to be sought. Therefore the main goal of the study was to develop tablets able to protect entrapped probiotic bacteria from gastric acidity, thus providing an easily manufacturing scale-up dosage form to deliver probiotics to the vicinity of the human colon. Whey protein concentrate microparticles with Lactobacillus paracasei L26 were produced by spray-drying and incorporated in tablets with cellulose acetate phthalate and sodium croscarmellose. The viability of L. paracasei L.26 throughout tableting as well as its gastric resistance and release from the tablets were evaluated. Storage stability of L. paracasei L26 tablets was also performed by evaluation of viable cells throughout 60 days at 23°C and 33% relative humidity. A decrease of approximately one logarithmic cycle was observed after the acid stage and the release of L. paracasei L26 from the tablets occurred only after 4 h in the conditions tested. Microencapsulated L. paracasei L26 in tablets revealed some susceptibility to the storage conditions tested since the number of viable cells decreased 2 log cycles after 60 days of storage. However, the viability of L. paracasei L26 after 45 days of storage did not reveal significant susceptibility upon exposure to simulated gastrointestinal conditions. The developed probiotic tablets revealed to be potential vectors for delivering viable cells of L. paracasei L26 and probably other probiotics to persons/patients who might benefit from probiotic therapy. |
Mendeley readers
The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ireland | 1 | 1% |
| South Africa | 1 | 1% |
| Unknown | 84 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 19% |
| Student > Master | 11 | 13% |
| Researcher | 9 | 10% |
| Student > Bachelor | 7 | 8% |
| Student > Doctoral Student | 6 | 7% |
| Other | 14 | 16% |
| Unknown | 23 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 15 | 17% |
| Agricultural and Biological Sciences | 12 | 14% |
| Engineering | 6 | 7% |
| Biochemistry, Genetics and Molecular Biology | 5 | 6% |
| Medicine and Dentistry | 5 | 6% |
| Other | 12 | 14% |
| Unknown | 31 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 June 2013.
All research outputs
#20,195,024
of 22,712,476 outputs
Outputs from AAPS PharmSciTech
#1,329
of 1,466 outputs
Outputs of similar age
#247,292
of 278,823 outputs
Outputs of similar age from AAPS PharmSciTech
#20
of 20 outputs
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