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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Long noncoding RNAs and the genetics of cancer
|
|---|---|
| Published in |
British Journal of Cancer, May 2013
|
| DOI | 10.1038/bjc.2013.233 |
| Pubmed ID | |
| Authors |
S W Cheetham, F Gruhl, J S Mattick, M E Dinger |
| Abstract |
Cancer is a disease of aberrant gene expression. While the genetic causes of cancer have been intensively studied, it is becoming evident that a large proportion of cancer susceptibility cannot be attributed to variation in protein-coding sequences. This is highlighted by genome-wide association studies in cancer that reveal that more than 80% of cancer-associated SNPs occur in noncoding regions of the genome. In this review, we posit that a significant fraction of the genetic aetiology of cancer is exacted by noncoding regulatory sequences, particularly by long noncoding RNAs (lncRNAs). Recent studies indicate that several cancer risk loci are transcribed into lncRNAs and these transcripts play key roles in tumorigenesis. We discuss the epigenetic and other mechanisms through which lncRNAs function and how they contribute to each stage of cancer progression, understanding of which will be crucial for realising new opportunities in cancer diagnosis and treatment. Long noncoding RNAs play important roles in almost every aspect of cell biology from nuclear organisation and epigenetic regulation to post-transcriptional regulation and splicing, and we link these processes to the hallmarks and genetics of cancer. Finally, we highlight recent progress and future potential in the application of lncRNAs as therapeutic targets and diagnostic markers. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 498 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 5 | 1% |
| United States | 5 | 1% |
| Spain | 2 | <1% |
| Sweden | 2 | <1% |
| Germany | 1 | <1% |
| Turkey | 1 | <1% |
| Brazil | 1 | <1% |
| Australia | 1 | <1% |
| Finland | 1 | <1% |
| Other | 10 | 2% |
| Unknown | 469 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 108 | 22% |
| Researcher | 98 | 20% |
| Student > Master | 73 | 15% |
| Student > Bachelor | 64 | 13% |
| Student > Postgraduate | 29 | 6% |
| Other | 61 | 12% |
| Unknown | 65 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 190 | 38% |
| Biochemistry, Genetics and Molecular Biology | 123 | 25% |
| Medicine and Dentistry | 56 | 11% |
| Chemistry | 8 | 2% |
| Engineering | 8 | 2% |
| Other | 34 | 7% |
| Unknown | 79 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 September 2021.
All research outputs
#2,885,150
of 23,505,010 outputs
Outputs from British Journal of Cancer
#1,753
of 10,604 outputs
Outputs of similar age
#24,840
of 195,112 outputs
Outputs of similar age from British Journal of Cancer
#19
of 115 outputs
Altmetric has tracked 23,505,010 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 10,604 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.7. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 195,112 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 115 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.