| Title |
Phytochemicals from Cruciferous Vegetables, Epigenetics, and Prostate Cancer Prevention
|
|---|---|
| Published in |
The AAPS Journal, June 2013
|
| DOI | 10.1208/s12248-013-9504-4 |
| Pubmed ID | |
| Authors |
Gregory W. Watson, Laura M. Beaver, David E. Williams, Roderick H. Dashwood, Emily Ho |
| Abstract |
Epidemiological evidence has demonstrated a reduced risk of prostate cancer associated with cruciferous vegetable intake. Follow-up studies have attributed this protective activity to the metabolic products of glucosinolates, a class of secondary metabolites produced by crucifers. The metabolic products of glucoraphanin and glucobrassicin, sulforaphane, and indole-3-carbinol respectively, have been the subject of intense investigation by cancer researchers. Sulforaphane and indole-3-carbinol inhibit prostate cancer by both blocking initiation and suppressing prostate cancer progression in vitro and in vivo. Research has largely focused on the anti-initiation and cytoprotective effects of sulforaphane and indole-3-carbinol through induction of phases I and II detoxification pathways. With regards to suppressive activity, research has focused on the ability of sulforaphane and indole-3-carbinol to antagonize cell signaling pathways known to be dysregulated in prostate cancer. Recent investigations have characterized the ability of sulforaphane and indole-3-carbinol derivatives to modulate the activity of enzymes controlling the epigenetic status of prostate cancer cells. In this review, we will summarize the well-established, "classic" non-epigenetic targets of sulforaphane and indole-3-carbinol, and highlight more recent evidence supporting these phytochemicals as epigenetic modulators for prostate cancer chemoprevention. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 33% |
| Australia | 1 | 11% |
| United Kingdom | 1 | 11% |
| Unknown | 4 | 44% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 67% |
| Science communicators (journalists, bloggers, editors) | 2 | 22% |
| Scientists | 1 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 128 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | <1% |
| France | 1 | <1% |
| Australia | 1 | <1% |
| Unknown | 125 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 35 | 27% |
| Student > Master | 17 | 13% |
| Researcher | 16 | 13% |
| Student > Ph. D. Student | 12 | 9% |
| Student > Postgraduate | 8 | 6% |
| Other | 21 | 16% |
| Unknown | 19 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 29 | 23% |
| Medicine and Dentistry | 24 | 19% |
| Nursing and Health Professions | 15 | 12% |
| Biochemistry, Genetics and Molecular Biology | 15 | 12% |
| Chemistry | 6 | 5% |
| Other | 12 | 9% |
| Unknown | 27 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 January 2024.
All research outputs
#1,961,951
of 25,270,999 outputs
Outputs from The AAPS Journal
#47
of 1,398 outputs
Outputs of similar age
#16,133
of 202,722 outputs
Outputs of similar age from The AAPS Journal
#1
of 11 outputs
Altmetric has tracked 25,270,999 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,398 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one has done particularly well, scoring higher than 96% of its peers.
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We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.