Deleted in Malignant Brain Tumors 1 (DMBT1) exerts functions in the regulation of epithelial differentiation and inflammation and has been proposed as tumor suppressor. Since chronic inflammation is a hallmark of cholangiocarcinogenesis, the aim of the study was to investigate the expression of DMBT1 in biliary tract cancer (BTC) and to correlate the expression with clinicopathological data.
The expression of DMBT1 protein was examined immunohistochemically in 157 BTC patients (41 intrahepatic (ICC), 60 extrahepatic cholangiocarcinomas (ECC), and 56 adenocarcinomas of the gallbladder (GBAC)). Additionally, 56 samples of high grade biliary intraepithelial neoplasia (BilIN 3) and 92 corresponding samples of histological non-neoplastic biliary tract tissues were included. DMBT1 expression was significantly increased in BilIN 3 compared to normal tissue (P < 0.0001) and BTC (P < 0.0001). BTC showed no significant difference in DMBT1 expression compared to non-neoplastic biliary tissue (P = 0.315). Absent DMBT1 expression in non-neoplastic biliary tissue of BTC patients was associated with poorer survival (P = 0.027). DMBT1 expression was significantly correlated with patients' age (P < 0.001).
DMBT1 is differently expressed in cholangiocarcinogenesis and poorer patients survival rates are associated with absent DMBT1 expression in non-neoplastic biliary tissue, suggesting a tumorsuppressive role of DMBT1 in early cholangiocarcinogenesis. This article is protected by copyright. All rights reserved.
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