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Clinical, morphological and immunohistochemical evidence that small‐cell carcinoma of the ovary of hypercalcaemic type (SCCOHT) may be a primitive germ‐cell neoplasm

Overview of attention for article published in Histopathology, March 2017
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

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1 news outlet
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Title
Clinical, morphological and immunohistochemical evidence that small‐cell carcinoma of the ovary of hypercalcaemic type (SCCOHT) may be a primitive germ‐cell neoplasm
Published in
Histopathology, March 2017
DOI 10.1111/his.13177
Pubmed ID
Authors

W Glenn McCluggage, Leora Witkowski, Blaise A Clarke, William D Foulkes

Abstract

The histogenesis and cell lineage of small cell carcinoma of the ovary of hypercalcaemic type (SCCOHT) is unknown. We aim to provide evidence that this may be a primitive germ cell neoplasm arising from a teratoma. Following the identification of two cases of SCCOHT associated with germ cell tumours (one dermoid cyst, one immature teratoma with a focus of yolk sac tumour), we undertook a literature review to look for any prior reports of SCCOHT in association with other neoplasms or elements. This revealed two cases associated with immature teratomas, one arising in an ovary where a cystectomy had previously been undertaken for a teratoma and another arising in association with a mucinous borderline tumour. Mucinous elements have also been reported in SCCOHT, this type of epithelium potentially being of teratomatous derivation. We stained whole tissue sections of 9 cases of SCCOHT and a tissue microarray (TMA) containing 34 different SCCOHT with germ cell markers SALL4, OCT3/4, alpha fetoprotein (AFP) and glypican 3. All except one of the whole tissue sections and approximately half of the TMA cases were positive with SALL4 while all cases were OCT3/4, AFP and glypican 3 negative, except for focal glypican 3 staining in an occasional case. Our findings provide additional evidence to that proposed by others that SCCOHT is a primitive germ cell neoplasm arising from a teratoma. This article is protected by copyright. All rights reserved.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 4%
Unknown 23 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 17%
Other 4 17%
Student > Postgraduate 2 8%
Student > Doctoral Student 1 4%
Student > Bachelor 1 4%
Other 4 17%
Unknown 8 33%
Readers by discipline Count As %
Medicine and Dentistry 10 42%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Agricultural and Biological Sciences 1 4%
Biochemistry, Genetics and Molecular Biology 1 4%
Unknown 11 46%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 June 2023.
All research outputs
#2,850,370
of 24,561,012 outputs
Outputs from Histopathology
#247
of 3,414 outputs
Outputs of similar age
#51,242
of 314,085 outputs
Outputs of similar age from Histopathology
#2
of 59 outputs
Altmetric has tracked 24,561,012 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,414 research outputs from this source. They receive a mean Attention Score of 4.8. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,085 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 59 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.