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Unbiased Approach for Virus Detection in Skin Lesions

Overview of attention for article published in PLOS ONE, June 2013
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Title
Unbiased Approach for Virus Detection in Skin Lesions
Published in
PLOS ONE, June 2013
DOI 10.1371/journal.pone.0065953
Pubmed ID
Authors

Davit Bzhalava, Hanna Johansson, Johanna Ekström, Helena Faust, Birgitta Möller, Carina Eklund, Peter Nordin, Bo Stenquist, John Paoli, Bengt Persson, Ola Forslund, Joakim Dillner

Abstract

To assess presence of virus DNA in skin lesions, swab samples from 82 squamous cell carcinomas of the skin (SCCs), 60 actinic keratoses (AKs), paraffin-embedded biopsies from 28 SCCs and 72 kerathoacanthomas (KAs) and fresh-frozen biopsies from 92 KAs, 85 SCCs and 92 AKs were analyzed by high throughput sequencing (HTS) using 454 or Ion Torrent technology. We found total of 4,284 viral reads, out of which 4,168 were Human Papillomavirus (HPV)-related, belonging to 15 known (HPV8, HPV12, HPV20, HPV36, HPV38, HPV45, HPV57, HPV59, HPV104, HPV105, HPV107, HPV109, HPV124, HPV138, HPV147), four previously described putative (HPV 915 F 06 007 FD1, FA73, FA101, SE42) and two putatively new HPV types (SE46, SE47). SE42 was cloned, sequenced, designated as HPV155 and found to have 76% similarity to the most closely related known HPV type. In conclusion, an unbiased approach for viral DNA detection in skin tumors has found that, although some new putative HPVs were found, known HPV types constituted most of the viral DNA.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 2%
Unknown 45 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 20%
Researcher 7 15%
Other 6 13%
Student > Postgraduate 5 11%
Student > Master 5 11%
Other 4 9%
Unknown 10 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 43%
Biochemistry, Genetics and Molecular Biology 5 11%
Medicine and Dentistry 5 11%
Computer Science 1 2%
Environmental Science 1 2%
Other 2 4%
Unknown 12 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 July 2013.
All research outputs
#17,690,900
of 22,713,403 outputs
Outputs from PLOS ONE
#146,599
of 193,923 outputs
Outputs of similar age
#140,495
of 195,446 outputs
Outputs of similar age from PLOS ONE
#3,506
of 4,784 outputs
Altmetric has tracked 22,713,403 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,923 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 195,446 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4,784 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.