| Title |
MiR-320a is Downregulated in Patients with Myasthenia Gravis and Modulates Inflammatory Cytokines Production by Targeting Mitogen-activated Protein Kinase 1
|
|---|---|
| Published in |
Journal of Clinical Immunology, November 2012
|
| DOI | 10.1007/s10875-012-9834-5 |
| Pubmed ID | |
| Authors |
Zhuoan Cheng, Shaobo Qiu, Lin Jiang, Anle Zhang, Wenjing Bao, Ping Liu, Jianwen Liu |
| Abstract |
Myasthenia gravis (MG) are T-cell dependent antibody-mediated autoimmune disorders, microRNAs are important regulators of human autoimmune disease pathogenesis. Here, we investigated the miRNAs expression profiles in MG for the first time and found that miR-320a was significantly downregulated in MG patients compared to normal healthy people. Meanwhile, pro-inflammatory cytokins in MG patients were overexpressed. Furthermore, we identified MAPK1 as a direct target of miR-320a. Downregulation of miR-320a induced the overexpression of pro-inflammatory cytokins through promoting COX-2 expression. This process was modulated by ERK/ NF-κB pathways. Taken together, our findings suggested that miR-320a could play a role in modulation of inflammatory cytokins production. |
Mendeley readers
The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 2% |
| Unknown | 44 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 22% |
| Student > Ph. D. Student | 7 | 16% |
| Student > Master | 6 | 13% |
| Student > Doctoral Student | 4 | 9% |
| Professor > Associate Professor | 3 | 7% |
| Other | 6 | 13% |
| Unknown | 9 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 18 | 40% |
| Biochemistry, Genetics and Molecular Biology | 5 | 11% |
| Agricultural and Biological Sciences | 5 | 11% |
| Neuroscience | 2 | 4% |
| Mathematics | 1 | 2% |
| Other | 4 | 9% |
| Unknown | 10 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2013.
All research outputs
#20,195,877
of 22,713,403 outputs
Outputs from Journal of Clinical Immunology
#1,254
of 1,560 outputs
Outputs of similar age
#245,417
of 276,727 outputs
Outputs of similar age from Journal of Clinical Immunology
#15
of 27 outputs
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