You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
The role of weight loss and exercise in correcting skeletal muscle mitochondrial abnormalities in obesity, diabetes and aging
|
|---|---|
| Published in |
Molecular & Cellular Endocrinology, June 2013
|
| DOI | 10.1016/j.mce.2013.06.018 |
| Pubmed ID | |
| Authors |
Frederico G.S. Toledo, Bret H. Goodpaster |
| Abstract |
Mitochondria within skeletal muscle have been implicated in insulin resistance of obesity and type 2 diabetes mellitus as well as impaired muscle function with normal aging. Evaluating the potential of interventions to improve mitochondria is clearly relevant to the prevention or treatment of metabolic diseases and age-related dysfunction. This review provides an overview and critical evaluation of the effects of weight loss and exercise interventions on skeletal muscle mitochondria, along with implications for insulin resistance, obesity, type 2 diabetes and aging. The available literature strongly suggests that the lower mitochondrial capacity associated with obesity, type 2 diabetes and aging is not an irreversible lesion. However, weight loss does not appear to affect this response, even when the weight loss is extreme. In contrast, increasing physical activity improves mitochondrial content and perhaps the function of individual mitochondrion. Despite the consistent effect of exercise to improve mitochondrial capacity, studies mechanistically linking mitochondria to insulin resistance, reductions in intramyocellular lipid or improvement in muscle function remain inconclusive. In summary, studies of diet and exercise training have advanced our understanding of the link between mitochondrial oxidative capacity and insulin resistance in obesity, type 2 diabetes and aging. Nevertheless, additional inquiry is necessary to establish the significance and clinical relevance of those perturbations, which could lead to targeted therapies for a myriad of conditions and diseases involving mitochondria. |
X Demographics
The data shown below were collected from the profiles of 15 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 27% |
| Australia | 3 | 20% |
| Japan | 1 | 7% |
| Switzerland | 1 | 7% |
| New Zealand | 1 | 7% |
| United Kingdom | 1 | 7% |
| Chile | 1 | 7% |
| Unknown | 3 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 47% |
| Scientists | 5 | 33% |
| Practitioners (doctors, other healthcare professionals) | 2 | 13% |
| Unknown | 1 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 177 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 2% |
| United States | 3 | 2% |
| Spain | 2 | 1% |
| Mexico | 1 | <1% |
| Chile | 1 | <1% |
| Japan | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 165 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 31 | 18% |
| Student > Master | 28 | 16% |
| Student > Bachelor | 25 | 14% |
| Student > Doctoral Student | 14 | 8% |
| Researcher | 14 | 8% |
| Other | 33 | 19% |
| Unknown | 32 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 48 | 27% |
| Sports and Recreations | 26 | 15% |
| Agricultural and Biological Sciences | 21 | 12% |
| Biochemistry, Genetics and Molecular Biology | 11 | 6% |
| Nursing and Health Professions | 9 | 5% |
| Other | 23 | 13% |
| Unknown | 39 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 March 2022.
All research outputs
#2,063,247
of 25,374,917 outputs
Outputs from Molecular & Cellular Endocrinology
#92
of 2,949 outputs
Outputs of similar age
#17,232
of 209,230 outputs
Outputs of similar age from Molecular & Cellular Endocrinology
#1
of 30 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,949 research outputs from this source. They receive a mean Attention Score of 4.8. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 209,230 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.