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Mendeley readers
Attention Score in Context
| Title |
The PIDDosome activates p53 in response to supernumerary centrosomes
|
|---|---|
| Published in |
Genes & Development, January 2017
|
| DOI | 10.1101/gad.289728.116 |
| Pubmed ID | |
| Authors |
Luca L. Fava, Fabian Schuler, Valentina Sladky, Manuel D. Haschka, Claudia Soratroi, Lisa Eiterer, Egon Demetz, Guenter Weiss, Stephan Geley, Erich A. Nigg, Andreas Villunger |
| Abstract |
Centrosomes, the main microtubule-organizing centers in animal cells, are replicated exactly once during the cell division cycle to form the poles of the mitotic spindle. Supernumerary centrosomes can lead to aberrant cell division and have been causally linked to chromosomal instability and cancer. Here, we report that an increase in the number of mature centrosomes, generated by disrupting cytokinesis or forcing centrosome overduplication, triggers the activation of the PIDDosome multiprotein complex, leading to Caspase-2-mediated MDM2 cleavage, p53 stabilization, and p21-dependent cell cycle arrest. This pathway also restrains the extent of developmentally scheduled polyploidization by regulating p53 levels in hepatocytes during liver organogenesis. Taken together, the PIDDosome acts as a first barrier, engaging p53 to halt the proliferation of cells carrying more than one mature centrosome to maintain genome integrity. |
Mendeley readers
The data shown below were compiled from readership statistics for 166 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 166 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 30 | 18% |
| Student > Ph. D. Student | 29 | 17% |
| Student > Master | 21 | 13% |
| Student > Bachelor | 15 | 9% |
| Professor > Associate Professor | 10 | 6% |
| Other | 22 | 13% |
| Unknown | 39 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 69 | 42% |
| Agricultural and Biological Sciences | 32 | 19% |
| Medicine and Dentistry | 8 | 5% |
| Immunology and Microbiology | 3 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 1% |
| Other | 9 | 5% |
| Unknown | 43 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 January 2017.
All research outputs
#2,374,738
of 25,837,817 outputs
Outputs from Genes & Development
#599
of 6,008 outputs
Outputs of similar age
#47,191
of 425,910 outputs
Outputs of similar age from Genes & Development
#14
of 43 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,008 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.1. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 425,910 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.