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Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

Overview of attention for article published in Nature Genetics, January 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

news
29 news outlets
blogs
4 blogs
twitter
188 X users
patent
1 patent
facebook
8 Facebook pages

Citations

dimensions_citation
480 Dimensions

Readers on

mendeley
653 Mendeley
citeulike
5 CiteULike
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Title
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
Published in
Nature Genetics, January 2017
DOI 10.1038/ng.3768
Pubmed ID
Authors

Helen R Warren, Evangelos Evangelou, Claudia P Cabrera, He Gao, Meixia Ren, Borbala Mifsud, Ioanna Ntalla, Praveen Surendran, Chunyu Liu, James P Cook, Aldi T Kraja, Fotios Drenos, Marie Loh, Niek Verweij, Jonathan Marten, Ibrahim Karaman, Marcelo P Segura Lepe, Paul F O'Reilly, Joanne Knight, Harold Snieder, Norihiro Kato, Jiang He, E Shyong Tai, M Abdullah Said, David Porteous, Maris Alver, Neil Poulter, Martin Farrall, Ron T Gansevoort, Sandosh Padmanabhan, Reedik Mägi, Alice Stanton, John Connell, Stephan J L Bakker, Andres Metspalu, Denis C Shields, Simon Thom, Morris Brown, Peter Sever, Tõnu Esko, Caroline Hayward, Pim van der Harst, Danish Saleheen, Rajiv Chowdhury, John C Chambers, Daniel I Chasman, Aravinda Chakravarti, Christopher Newton-Cheh, Cecilia M Lindgren, Daniel Levy, Jaspal S Kooner, Bernard Keavney, Maciej Tomaszewski, Nilesh J Samani, Joanna M M Howson, Martin D Tobin, Patricia B Munroe, Georg B Ehret, Louise V Wain

Abstract

Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure loci. In combination with results from a range of in silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure-raising genetic variants on future cardiovascular disease risk.

X Demographics

X Demographics

The data shown below were collected from the profiles of 188 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 653 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 <1%
Kenya 1 <1%
Germany 1 <1%
Canada 1 <1%
United States 1 <1%
Unknown 647 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 135 21%
Student > Ph. D. Student 110 17%
Student > Bachelor 56 9%
Student > Master 53 8%
Other 40 6%
Other 132 20%
Unknown 127 19%
Readers by discipline Count As %
Medicine and Dentistry 171 26%
Biochemistry, Genetics and Molecular Biology 116 18%
Agricultural and Biological Sciences 89 14%
Computer Science 22 3%
Nursing and Health Professions 16 2%
Other 78 12%
Unknown 161 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 354. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 May 2023.
All research outputs
#91,895
of 25,547,904 outputs
Outputs from Nature Genetics
#133
of 7,592 outputs
Outputs of similar age
#2,271
of 425,056 outputs
Outputs of similar age from Nature Genetics
#5
of 71 outputs
Altmetric has tracked 25,547,904 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,592 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.0. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 425,056 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 71 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.